Rhinosinusitis future or investigational therapies

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Dima Nimri, M.D. [2]

Overview

Topical corticosteroids with improved delivery route: Recently, there has been efforts to investigate the efficacy of topical corticosteroids in treatment of chronic rhinosinusitis in order to increase the efficacy of the anti-inflammatory agents and minimizes the long term side effects of the systemic agents. Large volume delivery and steroid-eluting stents are recent successful approaches for direct delivery of steroids to the paranasal sinuses. However the cost effectiveness and possible need for stent replacement are limitations that should be considered.
Monoclonal antibodies against inflammatory agents: Currently, monoclonal antibodies against IL-5, IL-4R and IgE have been administered systemically to the patients with severe forms of the disease, unresponsive to conventional therapy or patients with comorbid asthma. Systemic administration of these agents with considerable cost and side effects has limited their use.
Identifying predictors of patient compliance and treatment response:
Alternative or complementary therapies for surgery in recurrent cases:
Finding a "cure" for chronic rhinosinusitis: This could be possible by finding a method to correct the immune dysfunction in the patients.