Norovirus

	Norovirus infection Microchapters
Home
Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Norovirus infection from other Diseases
Epidemiology and Demographics
Risk Factors
Natural History, Complications and Prognosis
Diagnosis
Diagnostic study of choice
History and Symptoms
Physical Examination
Laboratory Findings
Treatment
Medical Therapy
Primary Prevention
Secondary Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
Norovirus On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Norovirus All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Norovirus
CDC on Norovirus
Norovirus in the news
Blogs on Norovirus
Directions to Hospitals Treating Norovirus infection
Risk calculators and risk factors for Norovirus

This page is about microbiologic aspects of the organism(s). For clinical aspects of the disease, see Norovirus infection.

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Norovirus is the cause of norovirus infection. Noroviruses (genus Norovirus) are a group of related, single-stranded RNA, nonenveloped viruses that cause acute gastroenteritis in humans. Noroviruses belong to the family Caliciviridae.

Causes

Common Causes

Less Common Causes

Virology

Life Cycle

Norovirus has a cytoplasmic replication. It attaches to the host receptors and enters the cell through endocytosis. Since, it is a positive sense virus, replication and transcription follows the corresponding models for positive stranded RNA viruses. Translation occurs by leaky scanning, and RNA termination-reinitiation.^[1]

Genus	Host Details	Tissue Tropism	Entry Details	Release Details	Replication Site	Assembly Site	Transmission
Norovirus	Humans; mammals	Intestinal epithelium	Cell receptor endocytosis	Lysis	Cytoplasm	Cytoplasm	Oral-fecal

Gallery

Electron micrograph of the Norovirus. From Public Health Image Library (PHIL). ^[2]
Transmission electron micrograph (TEM) revealed some of the ultrastructural morphology displayed by Norovirus virions. From Public Health Image Library (PHIL). ^[2]
Transmission electron micrograph (TEM) revealed some of the ultrastructural morphology displayed by Norovirus virions. From Public Health Image Library (PHIL). ^[2]
Transmission electron micrograph (TEM) revealed some of the ultrastructural morphology displayed by Norovirus virions. From Public Health Image Library (PHIL). ^[2]
Transmission electron micrograph (TEM) revealed some of the ultrastructural morphology displayed by Norovirus virions. From Public Health Image Library (PHIL). ^[2]
Transmission electron micrograph (TEM) revealed some of the ultrastructural morphology displayed by Norovirus virions. From Public Health Image Library (PHIL). ^[2]
Transmission electron micrograph (TEM) revealed some of the ultrastructural morphology displayed by Norovirus virions. From Public Health Image Library (PHIL). ^[2]