Urinary incontinence in children

Jump to navigation Jump to search

Urinary incontinence in children Microchapters

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differential Diagnosis

Epidemiology and Demographics

Risk factors

Natural History, Complications and Prognosis

Diagnosis

Treatment

Prevention

WikiDoc Resources for Urinary incontinence in children

Articles

Most recent articles on Urinary incontinence in children

Most cited articles on Urinary incontinence in children

Review articles on Urinary incontinence in children

Articles on Urinary incontinence in children in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Urinary incontinence in children

Images of Urinary incontinence in children

Photos of Urinary incontinence in children

Podcasts & MP3s on Urinary incontinence in children

Videos on Urinary incontinence in children

Evidence Based Medicine

Cochrane Collaboration on Urinary incontinence in children

Bandolier on Urinary incontinence in children

TRIP on Urinary incontinence in children

Clinical Trials

Ongoing Trials on Urinary incontinence in children at Clinical Trials.gov

Trial results on Urinary incontinence in children

Clinical Trials on Urinary incontinence in children at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Urinary incontinence in children

NICE Guidance on Urinary incontinence in children

NHS PRODIGY Guidance

FDA on Urinary incontinence in children

CDC on Urinary incontinence in children

Books

Books on Urinary incontinence in children

News

Urinary incontinence in children in the news

Be alerted to news on Urinary incontinence in children

News trends on Urinary incontinence in children

Commentary

Blogs on Urinary incontinence in children

Definitions

Definitions of Urinary incontinence in children

Patient Resources / Community

Patient resources on Urinary incontinence in children

Discussion groups on Urinary incontinence in children

Patient Handouts on Urinary incontinence in children

Directions to Hospitals Treating Urinary incontinence in children

Risk calculators and risk factors for Urinary incontinence in children

Healthcare Provider Resources

Symptoms of Urinary incontinence in children

Causes & Risk Factors for Urinary incontinence in children

Diagnostic studies for Urinary incontinence in children

Treatment of Urinary incontinence in children

Continuing Medical Education (CME)

CME Programs on Urinary incontinence in children

International

Urinary incontinence in children en Espanol

Urinary incontinence in children en Francais

Business

Urinary incontinence in children in the Marketplace

Patents on Urinary incontinence in children

Experimental / Informatics

List of terms related to Urinary incontinence in children

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Ifeoma Anaya, M.D.[2]

Synonyms and keywords: Urinary incontinence in kids; bedwetting; enuresis; nocturnal enuresis; enuresis nocturna; monosymptomatic enuresis nocturnal (MEN); non-monosymtomatic enuresis nocturnal (non-MEN)

Overview

Historical Perspective

  • Earliest documentation of urinary incontinence dates back to 1550 BC in the Ebers papyrus.
  • Pliny the elder, in 77 AD wrote on how incontinence of urine in children is treated by giving boiled mice in their food.
  • Paulus Bagellardus of Padua wrote on the distress experienced by parents due to bedwetting when infants after the age of 3 years 'continue to pass water in the bed' which can sometimes last beyond the period of puberty.
  • In 1891, Jacobi inserted a suppository into the rectum multiple times a day for reinforcement of a supposedly weak bladder to treat enuresis. The suppository was a mixture of old sheep fat and strychnine.[1]
  • Rhazes, the Persian clinician, identified some causes of enuresis in children to be:
    • Bladder outlet muscle relaxation.
    • Deep sleep.
    • Unrestricted fluid intake prior to bedtime, etc.[2]
  • Some of his treatment protocols included:
    • Minimizing fluid intake before bedtime.
    • Intake of substances producing fluid retention and body fluid losses.
    • Use of both oral and injectable medications to the bladder through the urethra.[2]
  • The term 'enuresis' was formed in 1790 which means 'to urinate within' and 'nocturnal' which means 'nighttime occurrence'. [2]

Classification

  • Urinary incontinence, also known as 'bedwetting' or 'enuresis' can be classified as follows:
Classification of Urinary Incontinence in Children
Types of urinary incontinence Details
Physiological
  • It is expected and seen as a norm in the early years.
  • Requires a minimum age of 5 years, at least one event in a month, and a minimum period of 3 months.
  • Persisting beyond the age of 5 years is termed pathological.
  • However, there are the 'late developers' who continue to experience physiologic urinary incontinence beyond the age of 5 years.
  • Clinical evaluation of these kids remains normal.[3]
Pathological Organic:
  • Usually uncommon.
  • In-depth investigations needed to be identified more so in cases that have not responded to conventional treatment.[3]
Functional or psychosomatic:
  • Includes all forms of pathological urinary incontinence without anatomic or neurologic defects.
  • Manifestations of which have been subdivided into two:
Monosymtomatic enuresis(MEN):
  • These kids have never had a dry period of >6 months and in the absence of any bladder dysfunction or symptoms suggestive of lower urinary tract issues.[4]
Non-monosymptomatic enuresis Nocturna(Non-MEN):
  • Diurnal presentation with an urge, frequency, and enuresis.[5]
  • Another form of classification is based on the course of nocturnal enuresis is:
    • Primary nocturnal enuresis: 6 consecutive months without ever achieving bladder control at night. Most common form.
    • Secondary nocturnal enuresis: 6 consecutive months of bladder control attained before a recurrence of incontinence. Could be related to an organic or psychological cause.[5]

Pathophysiology

  • The pathophysiology of urinary incontinence in children, particularly enuresis can be described under 3 broad categories:
  • Increased urine production at night
    • The bladder can fill up easily at night as a result of an imbalance between the production of urine at night and the capacity of the bladder. This often leads to frequent awakenings to pass urine for children or incontinence for those with difficulties in waking up.[6]
    • Nocturnal production of the Antidiuretic hormone, ADH is higher when compared to daytime values.[7] Thus, the insufficient production of ADH in these children has been identified with a subsequent rise in urine production, frequency of which is 2 out of 3 children.[8]
  • Reduced bladder capacity at night/Increased contractions of the detrusor muscle
    • Studies have proposed a reduced bladder wall capacity to 70% of the expected values with an increase in the bladder wall thickness on ultrasound in children with majorly nocturnal enuresis. [9]
    • In addition to this, there is disinhibition in contractions of the bladder wall in about 30% of kids with enuresis.[10]
  • Awakening Disorder
    • The sudden urge to pass urine does not occur adequately in kids that are enuretic.
    • Chronic over-stimulation causing a down-regulation of the voiding center has been surmised by researchers.[11]

Causes

  • The causes of urinary incontinence in children are identified based on the subclassification of pathological incontinence.
  • Causes of MEN are not fully elucidated but are assumed to be a result of an interplay between the delayed maturation of the neurological bladder and how the production of urine is regulated.
  • Non-MEN is subcategorized based on its symptoms which is predominantly day-time. These symptoms include:
    • Overactive bladder
    • Discoordinated micturition
    • Infrequent voiding
  • Causes of organic incontinence which is usually rare include the following;
    • Structural renal problems such as:
      • Ectopic ureter
      • Malformed urethra
      • Duplex kidney
    • Anatomic neural disorders like:
      • Spina bifida
      • Neoplasms of the nervous system
      • Tethered cord syndrome
      • Sacral agenesis. [3]

Differentiating [disease name] from other Diseases

For further information about the differential diagnosis, click here.

Epidemiology and Demographics

Age

  • Children achieve the ability to control their bladder between the ages of 3 and 6 years.
  • This begins initially during the daytime and nighttime control is achieved a lot later.[3]
  • Nocturnal enuresis is still seen in 15%-20% of kids at 5 years old with a spontaneous recovery rate of 14% yearly.[12]
  • 10% of children still have nocturnal enuresis at the age of 7 years with daytime symptoms seen in 2%-9%.[3]

Gender

  • Nocturnal enuresis is seen more frequently in boys.[13]

Race

  • There is no documented racial predilection for enuresis.

Risk Factors

  • Age, before 5 years
  • Positive family history. Risk is highest when one parent had been a sufferer of enuresis
  • Family size
  • Birth order
  • Male gender
  • Low socioeconomic status
  • Constipation
  • History of urinary tract infection, diabetes,
  • Psychological:
    • Birth of a sibling [13]
    • ADHD
    • Anxiety
    • Change of school
    • New home
    • Divorce of parents

Natural History, Complications and Prognosis

  • Complications:
    • Poor self-esteem
    • Inability to socialize with peers
    • Mood disorders
    • Stress
    • General affectation of child and family's quality of life such as poor academic performance
  • Prognosis:
    • Generally good due to high chances of spontaneous resolution at the rate of 15% per year.
    • Due to slow response to conventional treatment like alarm therapy and Desmopressin, 20% will remain incontinent by adulthood.[14]

Diagnosis

  • The focus is to eliminate any potential organic cause of incontinence and to classify and identify the type of functional incontinence using detailed history and non-invasive procedures.
  • Identify any comorbidities which are mostly psychological occurring alongside incontinence. [3]

Symptoms

  • Fundamental diagnosis includes taking a detailed history using a standardized questionnaire. Some of the important questions to ask include:
    • Time of the day child wets self?
    • Pattern of occurrence (every night or every other night)?
    • Place of occurrence (at home)?
    • Frequency of restroom visits during the day and any at night?
    • How does the child pass urine?
    • Any colored stains on pants during the daytime?
    • Any holding movements seen?
    • Pattern of urine stream?
    • Any straining?
    • Child's drinking habits especially in the evenings?
    • Previous/recurrent urinary tract infections?
    • Constipation?
    • Encopresis?
    • Developmental delays?
    • Psychological issues?
    • Previous surgery?
    • Any stressful circumstances recently either at home or school?
    • Method of treatment of incontinence in the past?
  • A symptom or bladder diary is completed over a period of 14 days.

Physical Examination

  • Primary aim of a physical examination is to look for possible organic causes of incontinence and comorbidities.
    • Spinal malformations in the lumbosacral region:
      • Lipoma
      • Hair tufts
      • Dimpled sacrum
      • Gluteal folds that appear non-symmetric
      • Hemangiomas
    • Fecal impaction on palpation of the abdomen
    • Genital region:
      • Phimosis
      • Urine leak
      • Labial synechiae
      • Vulval inflammation
    • Anal area:
      • Soilage
    • Lower extremities:
      • Asymmetric reflexes
      • Atrophic muscles
      • Deformities on the foot
    • Assess developmental milestones attained
    • Assess child's behavior and screen for any behavioral abnormalities using appropriate questionnaires.

Laboratory Findings

  • Urinalysis
    • Essential to rule out urinary tract infection.
    • Changes in urine specific gravity suggesting Diabetes insipidus
    • Glucosuria for Diabetes mellitus
  • Lack of response to therapy/interventions and a diagnosis of Non-MEN will warrant further work-up.

Electrocardiogram

There are no ECG findings associated with this condition.

X-ray

There are no x-ray findings associated with urinary incontinence in children.

Echocardiography or Ultrasound

  • Ultrasonography is a useful tool when further diagnostics is required especially in situations of a likely organic cause or a lack of response to therapy. It can detect anomalies in the renal system such as:
    • Increase in thickness of the bladder wall
    • Dilated ureters
    • Hydronephrosis
    • Ureterocele
    • Duplex kidney
    • Distended rectum. [3]

CT scan

  • There are no CT scan findings associated with urinary incontinence in children. However, a CT scan may be helpful in the diagnosis of organic causes where a more detailed observation of anatomical abnormalities is required.

MRI

  • There are no MRI findings associated with urinary incontinence in children. However, an MRI may be helpful in the diagnosis of organic causes where a more detailed observation of anatomical abnormalities is required.

Other Imaging Findings

There are no other imaging findings associated with urinary incontinence in children.

Other Diagnostic Studies

  • Uroflowmetry: This shows the bladder's pattern of voiding. If this test comes out suspicious, further testing like the Irofloe-electromyography is required to observe pelvic floor details.[15]
  • Urodynamic studies: reveals problems associated with the capacity of the bladder, compliance (detrusor muscles).
    • Valuable for illustrating neurogenic bladder or issues related to obstruction of the bladder outlet. [16]

Treatment

  • Treatment modality is based on the following fundamental principles:
    • Encourage both patient and caregiver to undergo therapy.
    • Treat day-time symptoms prior to night-time in non-MEN.
    • Fecal incontinence where present should be treated first.
    • Psychiatric comorbidities should be treated concurrently.
    • Higher success rates documented with combined treatment modalities.
    • Continuous monitoring of treatment is highly necessary.[3]

Medical Therapy

Surgery

  • Surgery is the mainstay of therapy for [disease name].
  • [Surgical procedure] in conjunction with [chemotherapy/radiation] is the most common approach to the treatment of [disease name].
  • [Surgical procedure] can only be performed for patients with [disease stage] [disease name].

Prevention

  • There are no primary preventive measures available for [disease name].
  • Effective measures for the primary prevention of [disease name] include [measure1], [measure2], and [measure3].
  • Once diagnosed and successfully treated, patients with [disease name] are followed-up every [duration]. Follow-up testing includes [test 1], [test 2], and [test 3].

References

  1. Salmon, Michael A (2016). "An Historical Account of Nocturnal Enuresis and its Treatment". Proceedings of the Royal Society of Medicine. 68 (7): 443–445. doi:10.1177/003591577506800726. ISSN 0035-9157.
  2. 2.0 2.1 2.2 Changizi Ashtiyani S, Shamsi M, Cyrus A, Tabatabayei SM (2013). "Rhazes, a genius physician in the diagnosis and treatment of nocturnal enuresis in medical history". Iran Red Crescent Med J. 15 (8): 633–8. doi:10.5812/ircmj.5017. PMC 3918184. PMID 24578827.
  3. 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 Schultz-Lampel D, Steuber C, Hoyer PF, Bachmann CJ, Marschall-Kehrel D, Bachmann H (2011). "Urinary incontinence in children". Dtsch Arztebl Int. 108 (37): 613–20. doi:10.3238/arztebl.2011.0613. PMC 3187617. PMID 21977217.
  4. Zhu W, Che Y, Wang Y, Jia Z, Wan T, Wen J; et al. (2019). "Study on neuropathological mechanisms of primary monosymptomatic nocturnal enuresis in children using cerebral resting-state functional magnetic resonance imaging". Sci Rep. 9 (1): 19141. doi:10.1038/s41598-019-55541-9. PMC 6915704 Check |pmc= value (help). PMID 31844104.
  5. 5.0 5.1 Arda E, Cakiroglu B, Thomas DT (2016). "Primary Nocturnal Enuresis: A Review". Nephrourol Mon. 8 (4): e35809. doi:10.5812/numonthly.35809. PMC 5039962. PMID 27703953.
  6. Nevéus T, Läckgren G, Tuvemo T, Hetta J, Hjälmås K, Stenberg A (2000). "Enuresis--background and treatment". Scand J Urol Nephrol Suppl (206): 1–44. PMID 11196246.
  7. Tas T, Cakiroglu B, Hazar AI, Balci MB, Sinanoglu O, Nas Y; et al. (2014). "Monosymptomatic nocturnal enuresis caused by seasonal temperature changes". Int J Clin Exp Med. 7 (4): 1035–9. PMC 4057857. PMID 24955178.
  8. Rittig S, Knudsen UB, Nørgaard JP, Pedersen EB, Djurhuus JC (1989). "Abnormal diurnal rhythm of plasma vasopressin and urinary output in patients with enuresis". Am J Physiol. 256 (4 Pt 2): F664–71. doi:10.1152/ajprenal.1989.256.4.F664. PMID 2705537.
  9. Yeung CK, Sreedhar B, Leung VT, Metreweli C (2004). "Ultrasound bladder measurements in patients with primary nocturnal enuresis: a urodynamic and treatment outcome correlation". J Urol. 171 (6 Pt 2): 2589–94. doi:10.1097/01.ju.0000112978.54300.03. PMID 15118426.
  10. Watanabe H (1995). "Sleep patterns in children with nocturnal enuresis". Scand J Urol Nephrol Suppl. 173: 55–6, discussion 56-7. PMID 8719568.
  11. Yeung CK, Diao M, Sreedhar B (2008). "Cortical arousal in children with severe enuresis". N Engl J Med. 358 (22): 2414–5. doi:10.1056/NEJMc0706528. PMID 18509134.
  12. Arda, Ersan; Cakiroglu, Basri; Thomas, David T. (2016). "Primary Nocturnal Enuresis: A Review". Nephro-Urology Monthly. 8 (4). doi:10.5812/numonthly.35809. ISSN 2251-7006.
  13. 13.0 13.1 Nørgaard JP, Djurhuus JC, Watanabe H, Stenberg A, Lettgen B (1997). "Experience and current status of research into the pathophysiology of nocturnal enuresis". Br J Urol. 79 (6): 825–35. doi:10.1046/j.1464-410x.1997.00207.x. PMID 9202545.
  14. "StatPearls". 2020. PMID 31424765.
  15. Nevéus T, von Gontard A, Hoebeke P, Hjälmås K, Bauer S, Bower W; et al. (2006). "The standardization of terminology of lower urinary tract function in children and adolescents: report from the Standardisation Committee of the International Children's Continence Society". J Urol. 176 (1): 314–24. doi:10.1016/S0022-5347(06)00305-3. PMID 16753432.
  16. Yeung CK, Sihoe JD, Sit FK, Diao M, Yew SY (2004). "Urodynamic findings in adults with primary nocturnal enuresis". J Urol. 171 (6 Pt 2): 2595–8. doi:10.1097/01.ju.0000112790.72612.0a. PMID 15118427.