Back pain pathophysiology
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Back pain Microchapters |
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Diagnosis |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Zehra Malik, M.B.B.S[2]
Overview
Pathophysiology
Physiology
The normal physiology of [name of process] can be understood as follows:
Pathogenesis
- The exact pathogenesis of back pain depends on the underlying cause.
- Back pain can be broadly classified into inflammatory, mechanical, degenerative, oncologic and infectious.
| Type of back pain | Pathophysiology |
| Inflammatory | Inflammation of joints (sacroiliitis), inflammation of enthesis (attachment point for ligaments, capsule, tendons) |
| Mechanical | Traume, muscle sprain, extra weight on muscles (pregnancy, heavy lifting), |
| Oncologic | Central (inferior olive) |
| Degenerative | Central and cerebellar (olivocerebellar circuits) |
| Infectious | Central (basal ganglia) |
Genetics
[Disease name] is transmitted in [mode of genetic transmission] pattern.
OR
Genes involved in the pathogenesis of [disease name] include:
- [Gene1]
- [Gene2]
- [Gene3]
OR
The development of [disease name] is the result of multiple genetic mutations such as:
- [Mutation 1]
- [Mutation 2]
- [Mutation 3]
Associated Conditions
Conditions associated with [disease name] include:
- [Condition 1]
- [Condition 2]
- [Condition 3]
Gross Pathology
On gross pathology, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].
Microscopic Pathology
On microscopic histopathological analysis, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].