Clinical depression risk factors

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Kiran Singh, M.D. [2]

Overview

Risk factors for clinical depression include anxiety, positive family history, stressful life events, and substance abuse among others.[1]

Risk Factors

Risk factors for the developmement of major depressive disorder include: [1]

  • Genetic predipsosition:
    • First-degree relatives of patients with major depressive symptoms have two- to four-fold higher risk of developing major depressive disorder than of the general population
  • Personality trait (temperament):
    • Neuroticism (also known as Negative emotionality or Negative affectivity) is associated with an increased risk of developing major depressive disorder. Individuals with this personality trait are also more likely to experience depressive episodes in response to stressful life events.
  • Environmental factors:
    • Adverse childhood experiences, in particular with multiple and diverse types
    • Stressful life events
  • Course modifiers:
    • Major pschichaitric disorders increase the risk of developing major deprsesive disorder. The most common causes include:
      • Substance user
      • Anxiety
      • Borderline personality disorder
    • Chornic or disabling medical conditions increase the risk of developing major deprsesive disorder. The most common causes include:
      • Diabetes
      • Morbid obesity
      • Cardiovascular diseases

References

  1. 1.0 1.1 Diagnostic and statistical manual of mental disorders : DSM-5. Washington, D.C: American Psychiatric Association. 2013. ISBN 0890425558.

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