Clinical depression laboratory findings

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Laboratory Findings

*Dexamethasone suppression test

• • About 50% of patients with major depressive disorder have abnormal dexamethasone suppression test. Nonsuppression (positive test result) shows cortisol hypersecretion secondary to a hyperactive hypothalamus-pituitary-adrenal axis.
  • However, dexamethasone suppression test is not routinely used in the diagnosis of major depressive disorders due to high rates of false positives and false negatives.
• Diminished TSH in response to TRH and decreased prolactine release in response to tryptophan have been reported in patients with major depresion

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