Autoimmune lymphoproliferative syndrome other diagnostic studies
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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Overview
The histopathologic study may be helpful in the diagnosis of Autoimmune lymphoproliferative syndrome(ALPS). Findings suggestive of ALPS include paracortical expansion due to infiltration of polyclonal TCR α/β+ DNT cells, follicular hyperplasia, and polyclonal plasmacytosis.
Other Diagnostic Studies
Histopathological study findings can be helpful to diagnose Autoimmune lymphoproliferative syndrome. The findings are
- Paracortical expansion with infiltration of polyclonal TCR α/β+ DNT cells.[1]
- DNT cells express TIA-1 and CD57, CD45RO negative
- Follicular hyperplasia
- Polyclonal plasmacytosis
- Spleen has expanded T cell areas dominated by DNT cells.
References
- ↑ Li, Pu; Huang, Ping; Yang, Ye; Hao, Mu; Peng, Hongwei; Li, Fei (2015). "Updated Understanding of Autoimmune Lymphoproliferative Syndrome (ALPS)". Clinical Reviews in Allergy & Immunology. 50 (1): 55–63. doi:10.1007/s12016-015-8466-y. ISSN 1080-0549.