Asplenia history and symptoms
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Anum Dilip, M.B.B.S[2]
Overview
History and Symptoms
History
Patients with asplenia may have a positive history of:
- Trauma [1]
- Surgery
- Heterozygous coding mutations in RPSA.
- Genetic defect: connexin 43 and ZIC3 have been shown to be involved in heterotaxia syndromes.[2]
Common Symptoms
Common symptoms of asplenia include:
References
- ↑ Ahmed SA, Zengeya S, Kini U, Pollard AJ (2010). "Familial isolated congenital asplenia: case report and literature review". Eur J Pediatr. 169 (3): 315–8. doi:10.1007/s00431-009-1030-0. PMID 19618213.
- ↑ MYERSON RM, KOELLE WA (1956). "Congenital absence of the spleen in an adult; report of a case associated with recurrent Waterhouse-Friderichsen syndrome". N Engl J Med. 254 (24): 1131–2. doi:10.1056/NEJM195606142542406. PMID 13322226.
- ↑ Yildiz H, Yombi JC (2017). "Fever and asplenia: a dangerous association". BMJ Case Rep. 2017. doi:10.1136/bcr-2017-220513. PMC 5535142. PMID 28659372.
- ↑ Thiruppathy K, Privitera A, Jain K, Gupta S (2008). "Congenital asplenia and group B streptococcus sepsis in the adult: case report and review of the literature". FEMS Immunol Med Microbiol. 53 (3): 437–9. doi:10.1111/j.1574-695X.2008.00422.x. PMID 18564289.