Amyotrophic lateral sclerosis epidemiology and demographics

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Mohamadmostafa Jahansouz M.D.[2]

Overview

Between 1 to 2 people per 100,000 develop ALS each year . ALS most commonly strikes people between 40 and 60 years of age, but younger and older people can also develop the disease. Men are affected slightly more often than women. Although there have been reports of several "clusters" including three American football players from the San Francisco 49ers, three soccer-playing friends in the south of England, and reports of conjugal (i.e., husband and wife) cases in the south of France, these are statistically plausible chance events. Although many authors consider ALS to be caused by a combination of genetic and environmental risk factors, so far the latter have not been firmly identified, other than a higher risk with increasing age.

=Epidemiology and Demographics

Incidence

• The incidence of ALS is around 0.6-3.8 per 100000 person-years.

Prevalance

The prevalence of ALS is between 4.1-8.4 per 100000 person-years.

Age Onset

The median age of onset of ALS is between 51-66 years.

Gender

The male population is more commonly affected by ALS than females.

References

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