Autoimmune lymphoproliferative syndrome laboratory findings
|
Autoimmune lymphoproliferative syndrome Microchapters |
|
Differentiating Autoimmune lymphoproliferative syndrome from other Diseases |
|---|
|
Diagnosis |
|
Treatment |
|
Case Studies |
|
Autoimmune lymphoproliferative syndrome laboratory findings On the Web |
|
American Roentgen Ray Society Images of Autoimmune lymphoproliferative syndrome laboratory findings |
|
FDA on Autoimmune lymphoproliferative syndrome laboratory findings |
|
CDC on Autoimmune lymphoproliferative syndrome laboratory findings |
|
Autoimmune lymphoproliferative syndrome laboratory findings in the news |
|
Blogs on Autoimmune lymphoproliferative syndrome laboratory findings |
|
Directions to Hospitals Treating Autoimmune lymphoproliferative syndrome |
|
Risk calculators and risk factors for Autoimmune lymphoproliferative syndrome laboratory findings |
Editor-In-Chief: Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] David Teachey, MD [2] Associate Editor(s)-in-Chief: Sharmi Biswas, M.B.B.S
Overview
An elevated concentration of serum double negative α/β T cells comprising more than 1.5% of the total lymphocytes or at least 2.5% of total T cells along with chronic lymphadenopathy or splenomegaly for more than 6 months are the two required testing for clinical diagnosis of Autoimmune lymphoproliferative syndrome which leads to ancillary testing. Confirmatory testing for ALPS is the testing for the ALPS-related mutations or functional testing of patient T cells are requires according to the 2010 guidelines.
Laboratory Findings
In peripheral blood-
- Co-expression of CD45RA,CD57,CD27,CD28, perforin, and HLA-DR in the DNT cells but lacking CD45R0 and CD56
- Cytopenia
- Positive Coombs' test
- Increased soluble FAS ligand (FasL)
- High vitamin B12
- Hypergammaglobulinemia ( increased IgG, IgA,or IgM)