Diabetic neuropathy overview
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Diabetic neuropathies are neuropathic disorders that are associated with diabetes mellitus. These conditions are thought to result from diabetic microvascular injury involving small blood vessels that supply nerves (vasa nervorum). Relatively common conditions which may be associated with diabetic neuropathy include third nerve palsy; mononeuropathy; mononeuropathy multiplex; diabetic amyotrophy; a painful polyneuropathy; autonomic neuropathy; and thoracoabdominal neuropathy.
Historical Perspective
Little was known about the association of diabetes mellitus with neuropathy as a complication. In 1868, Charcot associated Charcot's Joint(a known complication of prolonged diabetes mellitus) as a complication of Tabes Dorsalis, but failed to establish an association with Diabetes Mellitus. It was not until the 1936, that W.R Jordan established the connection between Diabetes Mellitus, and it's neurogenic arthropathy.[1] [2]
Classification
Diabetic neuropathy can be classified into two main types:
- Sensorimotor
- Autonomic
Pathophysiology
Causes
Differentiating Diabetic neuropathy other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
History and Symptoms
Physical Examination
Laboratory Findings
Electrocardiogram
Chest X Ray
CT
MRI
Echocardiography or Ultrasound
Other Imaging Findings
Other Diagnostic Studies
Treatment
Surgery
Medical Therapy
Primary Prevention
Secondary Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
References
- ↑ Sanders LJ (2004). "The Charcot foot: historical perspective 1827-2003". Diabetes Metab Res Rev. 20 Suppl 1: S4–8. doi:10.1002/dmrr.451. PMID 15150805.
- ↑ Sanders LJ, Robbins JM, Edmonds ME (September 2010). "History of the team approach to amputation prevention: pioneers and milestones". J Vasc Surg. 52 (3 Suppl): 3S–16S. doi:10.1016/j.jvs.2010.06.002. PMID 20804927.
- ↑ Deli G, Bosnyak E, Pusch G, Komoly S, Feher G (2013). "Diabetic neuropathies: diagnosis and management". Neuroendocrinology. 98 (4): 267–80. doi:10.1159/000358728. PMID 24458095.