Primary ciliary dyskinesia natural history, complications and prognosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Hafsa Ghaffar, M.B.B.S[2]
Overview
The long-term effects of primary ciliary dyskinesia (PCD) are dependent on respiratory symptoms. PCD is not considered to be life-threatening, but persistent lung and airway disease can lead to permanent damage. Recurrent ear infections can lead to hearing loss, which is sometimes permanent, prompt diagnosis and early treatment improve long-term outcomes.
Natural History, Complications, and Prognosis
Natural History
Primary ciliary dyskinesia develops earlier in life, prognosis depends on the severity of associated symptoms. It is usually diagnosed after workup of persistent rhinorrhea, sinusitis, recurrent pneumonia, persistent otitis media, or infertility. age on onset directly correlates with disease severity and prognosis.
Complications
- Common complications of [disease name] include:
- [Complication 1]
- [Complication 2]
- [Complication 3]
Prognosis
- Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with [disease name] is approximately [--]%.
- Depending on the extent of the [tumor/disease progression] at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as poor/good/excellent.
- The presence of [characteristic of disease] is associated with a particularly [good/poor] prognosis among patients with [disease/malignancy].
- [Subtype of disease/malignancy] is associated with the most favorable prognosis.
- The prognosis varies with the [characteristic] of tumor; [subtype of disease/malignancy] have the most favorable prognosis.