Pyonephrosis pathophysiology
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Harsh Vardhan Chawla, M.B.B.S.[2]
Overview
Pyonephrosis can be seen as a complication of acute pyelonephritis, usually seen with complete or incomplete obstruction of tubules.
Pyonephrosis can be seen as a complication of acute pyelonephritis, usually seen with complete or incomplete obstruction of tubules[1].
Obstruction of ureter and renal pelvis causes dilatation of tubular system which in turn leads to hydronephrosis.
The dilatation of the tubular system serves as a nidus for infection because the pathogens multiply easily in obstructed and dilated tubules leading to suppurative inflammation.
The exudates fill the tubules, renal pelvis, calyces and ureter with pus that is difficult to drain.
The accumulation of pus in the tubules eventually lead to structural and functional loss of the renal parenchyma.
There may be a complete or incomplete loss of function initially.
The combination of obstruction with the infections may rapidly progresses to sepsis.
Therefore, it becomes critical to diagnose and treat the condition promptly, to prevent renal loss of function and blood stream infection leading to sepsis.
References
- ↑ Kumar, Vinay (2015). Robbins and Cotran pathologic basis of disease. Philadelphia, PA: Elsevier/Saunders. ISBN 978-1-4557-2613-4.