Monkeypox history and symptoms
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Bassel Almarie, M.D.
Overview
History
The significant information in the patient's history include:
- Recent travel to endemic area
- Recent contact with person with similar complains or infected person with monkeypox
Any history of travel to the endemic areas
Any ill contact with similar complaints
Vital Signs
Diagnostic Criteria
Interim clinical, laboratory and epidemiologic criteria for case classification — U.S. Monkeypox Response, May 2022
| Clinical and laboratory classification | Criteria |
| Suspected | New characteristic rash* OR |
| Meets one of the epidemiologic criteria and has high clinical suspicion† for monkeypox | |
| Probable | No suspicion of other recent orthopoxvirus exposure (e.g., Vaccinia virus in ACAM2000 vaccination) AND demonstration of the presence of |
| • Orthopoxvirus DNA by polymerase chain reaction testing of a clinical specimen OR | |
| • Orthopoxvirus using immunohistochemical or electron microscopy testing methods
OR | |
| • Detectable levels of antiorthopoxvirus IgM antibody during the period of 4–56 days after rash onset | |
| Confirmed | Demonstration of the presence of Monkeypox virus DNA by polymerase chain reaction testing or next-generation sequencing of a clinical specimen
OR |
| Isolation of Monkeypox virus in culture from a clinical specimen |