CYP2A7
| cytochrome P450, family 2, subfamily A, polypeptide 7 | |
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| Identifiers | |
| Symbol | CYP2A7 |
| Entrez | 1549 |
| HUGO | 2611 |
| RefSeq | NM_030589 |
| UniProt | P20853 |
| Other data | |
| EC number | 1.14.14.1 |
| Locus | Chr. 19 q13.2 |
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US National Guidelines Clearinghouse on CYP2A7
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CYP2A7 (cytochrome P450, family 2, subfamily A, polypeptide 7) is a protein which in humans is encoded by the CYP2A7 gene.[1][2]
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum; its substrate has not yet been determined. This gene, which produces two transcript variants, is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q.[3]
References
- ↑ Fernandez-Salguero P, Hoffman SM, Cholerton S, Mohrenweiser H, Raunio H, Rautio A, Pelkonen O, Huang JD, Evans WE, Idle JR (1995). "A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles". Am. J. Hum. Genet. 57 (3): 651–60. PMC 1801261. PMID 7668294. Unknown parameter
|month=ignored (help) - ↑ Nelson DR, Zeldin DC, Hoffman SM, Maltais LJ, Wain HM, Nebert DW (2004). "Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants". Pharmacogenetics. 14 (1): 1–18. PMID 15128046. Unknown parameter
|month=ignored (help) - ↑ "Entrez Gene: CYP2A7".
This article incorporates text from the United States National Library of Medicine, which is in the public domain.