CYP2B6

cytochrome P450, family 2, subfamily B, polypeptide 6
Identifiers
Symbol	CYP2B6
Entrez	1555
HUGO	2615
OMIM	123930
RefSeq	NM_000767
UniProt	P20813
Other data
Locus	Chr. 19 q13.2

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CYP2B6 is a member of the Cytochrome P450 group of enzymes. Along with CYP2A6, it is involved with metabolizing nicotine, along with many other substances.

CYP2B6 Ligands

Substrates	Inhibitors	Inducers
Often mentioned : Bupropion (antidepressant) Cyclophosphamide (Alkylating antineoplastic agent) Efavirenz (NNRTI) Ifosfamide (Alkylating antineoplastic agent) Other: Alfentanil (opioid analgesic) Nevirapine (NNRTI) Propofol (anesthetic) tamoxifen (SERM) Valproic acid (anticonvulsant , mood-stabilizing) Artemisinin (against malaria) Pethidine (analgesic) Nicotine (stimulant) Sertraline (SSRI) thiotepa (Alkylating antineoplastic agent)	Strong : Orphenadrine (analgesic) unspecified: Paroxetine (SSRI) fluoxetine (SSRI) Estradiol (sex hormone) Phencyclidine (dissociative) ritonavir (antiretroviral) sertraline (SSRI) thiotepa (Alkylating antineoplastic agent) ticlopidine (antiplatelet)	Often mentioned : carbamazepine (anticonvulsant, mood stabilizer) rifampicin (bactericidal) Other: artemisinin (against malaria) clotrimazole (antifungal) ifosfamide (Alkylating antineoplastic agent) glucocorticoids (antiinflammatory) phenobarbital (anticonvulsant ) phenytoin (antiepileptic) ritonavir (antiretroviral)

External links

• CYP2B6 at the US National Library of Medicine Medical Subject Headings (MeSH)