CYP2S1

Cytochrome P450, family 2, subfamily S, polypeptide 1
Identifiers
Symbols	CYP2S1 ;
External IDs	Template:MGI HomoloGene: 75274
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

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Evidence Based Medicine
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Guidelines / Policies / Govt
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Commentary
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Definitions
Definitions of CYP2S1
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Continuing Medical Education (CME)
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Experimental / Informatics
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Cytochrome P450, family 2, subfamily S, polypeptide 1, also known as CYP2S1, is a human gene.

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolize certain carcinogens; however, the specific function of the human protein has not been determined.

Further reading

• Adams MD, Kerlavage AR, Fleischmann RD; et al. (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence". Nature. 377 (6547 Suppl): 3–174. PMID 7566098.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rylander T, Neve EP, Ingelman-Sundberg M, Oscarson M (2001). "Identification and tissue distribution of the novel human cytochrome P450 2S1 (CYP2S1)". Biochem. Biophys. Res. Commun. 281 (2): 529–35. doi:10.1006/bbrc.2001.4390. PMID 11181079.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Smith G, Wolf CR, Deeni YY; et al. (2003). "Cutaneous expression of cytochrome P450 CYP2S1: individuality in regulation by therapeutic agents for psoriasis and other skin diseases". Lancet. 361 (9366): 1336–43. PMID 12711469.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Saito S, Iida A, Sekine A; et al. (2003). "Catalog of 680 variations among eight cytochrome p450 ( CYP) genes, nine esterase genes, and two other genes in the Japanese population". J. Hum. Genet. 48 (5): 249–70. doi:10.1007/s10038-003-0021-7. PMID 12721789.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Clark HF, Gurney AL, Abaya E; et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rivera SP, Wang F, Saarikoski ST; et al. (2007). "A novel promoter element containing multiple overlapping xenobiotic and hypoxia response elements mediates induction of cytochrome P4502S1 by both dioxin and hypoxia". J. Biol. Chem. 282 (15): 10881–93. doi:10.1074/jbc.M609617200. PMID 17277313.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Marek CJ, Tucker SJ, Koruth M; et al. (2007). "Expression of CYP2S1 in human hepatic stellate cells". FEBS Lett. 581 (4): 781–6. doi:10.1016/j.febslet.2007.01.056. PMID 17280660.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hanzawa Y, Sasaki T, Hiratsuka M; et al. (2007). "Three novel single nucleotide polymorphisms (SNPs) of CYP2S1 gene in Japanese individuals". Drug Metab. Pharmacokinet. 22 (2): 136–40. PMID 17495422.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jang YJ, Cha EY, Kim WY; et al. (2007). "CYP2S1 gene polymorphisms in a Korean population". Therapeutic drug monitoring. 29 (3): 292–8. doi:10.1097/FTD.0b013e318058a4e0. PMID 17529885.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)