Primitive neuroectodermal tumor

Primitive neuroectodermal tumor
ICD-O:	M9473/3
DiseasesDB	31470
eMedicine	ped/2589  neuro/326
MeSH	D018242

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Overview

Primitive Neuroectodermal Tumors, or PNET, refers to two different tumor types. These include Peripheral PNET and CNS PNET. This can be a source of confusion.

Some PNET Types

Peripheral PNET

The Peripheral PNET is now thought to be virually identical to Ewing sarcoma:

"Current evidence indicates that both Ewing's sarcoma and PNET have a similar neural phenotype and, because they share an identical chromosome translocation, they should be viewed as the same tumor, differing only in their degree of neural differentiation. Tumors that demonstrate neural differentiation by light microscopy, immunohistochemistry, or electron microscopy have been traditionally labeled PNETs, and those that are undifferentiated by these analyses have been diagnosed as Ewing's sarcoma."

PNET of the CNS

PNET of the CNS are grossly divided into supratentorial PNET and infratentorial PNET, the latter being more common.

An example of infratentorial PNET includes Medulloblastomas, which occurs in the cerebellum.

An example of supratentorial PNET includes Pinealoblastomas, which occurs in the pineal region.

Acknowledgements

The content on this page was first contributed by: C. Michael Gibson, M.S., M.D.

Initial content for this page in some instances came from Wikipedia

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