Terfenadine

Terfenadine

Clinical data
ATC code	R06AX12 (WHO)
Pharmacokinetic data
Protein binding	70%
Elimination half-life	3.5 hours
Identifiers
IUPAC name 4-[4-(hydroxy-diphenyl-methyl)-1-piperidyl]- 1-(4-tert-butylphenyl)-butan-1-ol
CAS Number	50679-08-8
PubChem CID	5405
DrugBank	APRD00606
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C32H41NO2
Molar mass	471.673 g/mol

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Evidence Based Medicine
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Clinical Trials
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Guidelines / Policies / Govt
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Definitions
Definitions of Terfenadine
Patient Resources / Community
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Healthcare Provider Resources
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Continuing Medical Education (CME)
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Experimental / Informatics
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Overview

Terfenadine is an antihistamine formerly used for the treatment of allergic conditions. It was marketed under various brand names including Seldane in the United States, Triludan in the United Kingdom, and Teldane in Australia. It was superseded by fexofenadine in the 1990s due to the risk of cardiac arrhythmia caused by QT interval prolongation.

Terfenadine is a prodrug, generally completely metabolised to the active form fexofenadine by intestinal CYP3A4. Terfenadine itself, however, has a cardiotoxic effect and may be absorbed and reach myocytes if the patient is concurrently taking a CYP3A4 inhibitor (e.g. erythromycin, grapefruit juice).