Motilin
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Phone:617-632-7753
Please Join in Editing This Page and Apply to be an Editor-In-Chief for this topic: There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us [2] to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch.
Overview
| Motilin/ghrelin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Motilin_ghrelin | ||||||||
| Pfam | PF04644 | ||||||||
| InterPro | IPR006738 | ||||||||
| SCOP | 1lbj | ||||||||
| SUPERFAMILY | 1lbj | ||||||||
| OPM superfamily | 154 | ||||||||
| OPM protein | 1lbj | ||||||||
| |||||||||
| Motilin | |
|---|---|
| Identifiers | |
| Symbol | MLN |
| Entrez | 4295 |
| HUGO | 7141 |
| OMIM | 158270 |
| RefSeq | NM_001040109 |
| UniProt | P12872 |
| Other data | |
| Locus | Chr. 6 p21.3-p21.2 |
|
WikiDoc Resources for Motilin |
|
Articles |
|---|
|
Most recent articles on Motilin |
|
Media |
|
Evidence Based Medicine |
|
Clinical Trials |
|
Ongoing Trials on Motilin at Clinical Trials.gov Clinical Trials on Motilin at Google
|
|
Guidelines / Policies / Govt |
|
US National Guidelines Clearinghouse on Motilin
|
|
Books |
|
News |
|
Commentary |
|
Definitions |
|
Patient Resources / Community |
|
Directions to Hospitals Treating Motilin Risk calculators and risk factors for Motilin
|
|
Healthcare Provider Resources |
|
Causes & Risk Factors for Motilin |
|
Continuing Medical Education (CME) |
|
International |
|
|
|
Business |
|
Experimental / Informatics |
Overview
Motilin is a polypeptide hormone secreted by Mo cells of the small intestine that increases the migrating myoelectric complex component of gastrointestinal motility and stimulates the production of pepsin. Control of motilin secretion is largely unknown, although some studies suggest that an alkaline pH in the duodenum stimulates its release. Interestingly however, at low pH it inhibits gastric motor activity, whereas at high pH it has a stimulatory effect.
Apart from in humans, motilin receptors are found in pigs', rats',cows' and cats' gastrointestinal tracts and in rabbits' central nervous systems.
Motilin agonists
Erythromycin and related antibiotics act as non-peptide motilin agonists, and are sometimes used for their ability to stimulate gastrointestinal motility. Administration of a low dose of erythromycin will induce peristalsis, which provides additional support for the conclusion that motilin secretion triggers this pattern of gastrointestinal motility, rather than results from it. However, some of erythromycin’s properties, including antibiotic activity, are not appropriate for a drug designed for chronic use over a patient's lifetime.
New motilin agonists are erythromycin based, however, it may be that this class of drugs becomes redundant; growth hormone secretagogue receptors share 52% of their DNA with motilin receptors and agonists of these receptors, termed ghrelins, can bring about similar effects to motilin agonists.
Related peptides
This domain is also found in ghrelin, a growth hormone secretagogue synthesised by endocrine cells in the stomach. Ghrelin stimulates growth hormone secretagogue receptors in the pituitary. These receptors are distinct from the growth hormone-releasing hormone receptors, and thus provide a means of controlling pituitary growth hormone release by the gastr ointestinal system[1].
References
External links
- Essentials of Human Physiology by Thomas M. Nosek. Section 6/6ch2/s6ch2_26.
- Motilin at the US National Library of Medicine Medical Subject Headings (MeSH)