Intention to treat analysis
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Please Take Over This Page and Apply to be Editor-In-Chief for this topic: There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us [2] to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch.
Overview
In epidemiology, an intention to treat (ITT) analysis is an analysis based on the initial treatment intent, not on the treatment eventually administered. It is based on the assumption that, as in real life, sometimes patients do not all receive optimal treatment, even though that was the initial intention. For the purposes of analysis, the reasons why the patient did not receive the treatment are ignored.
Rationale
Intention to treat analyses are done to avoid the effects of crossover and drop-out, which may break the randomization to the treatment groups in a study. Intention to treat analysis provides information about the potential effects of treatment policy rather than on the potential effects of specific treatment.
In contrast, efficacy subset analysis selects the subset of the patients who received the treatment of interest--regardless of initial randomization--and who have not dropped out for any reason. This approach can :
- introduce biases to the statistical analysis
- inflate the type I error; this effect is greater the larger the trial[1].
Full application of intention to treat can only be performed where there is complete outcome data for all randomised subjects.
Although intention to treat is widely cited in published trials, it is often incorrectly described and its application may be flawed.
References
- ↑ Lachin JM (2000). "Statistical Considerations in the Intent-to-Treat Principle". Statistics in Medicine. 21 (3): 167–189. PMID 10822117. Unknown parameter
|month=ignored (help)
See also
External links
- Intention to Treat - Bandolier's definition
- Intention to Treat - Tufts.edu
- What is meant by intention to treat analysis? Survey of published randomised controlled trials - BMJ