Alkaptonuria (patient information)

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What is Alkaptonuria?

Alkaptonuria is a rare condition in which a person's urine turns a dark brownish-black color when exposed to air.

What are the symptoms of Alkaptonuria?

Urine in an infant's diaper may darken and can turn almost black after several hours. However, many persons with this condition may not know they have it until mid-adulthood (around age 40), when joint and other problems occur.

Symptoms may include:

• Arthritis (especially of the spine) that gets worse over time
• Darkening of the ear
• Dark spots on the white of the eye (sclera) and cornea