Aspirin desensitization

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [3]; Keri Shafer, M.D.

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Overview

Rapid aspirin desensitization is required when continued aspirin administration is urgent and essential (e.g. acute coronary syndrome). Based on Wong et al in May 2000, a rapid protocol can be used [1]

Protocol for Aspirin Desensitization:

The dose of aspirin is increased every 15 minutes until the maximum dose of aspirin is administered:

Dose #

  1. 0.1 mg
  2. 0.3 mg
  3. 1 mg
  4. 3 mg
  5. 10 mg
  6. 20 mg
  7. 40 mg
  8. 81 mg
  9. 162 mg
  10. 325 mg

[2]

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