Cardiac Resynchronization Therapy

WikiDoc Resources for Cardiac Resynchronization Therapy
Articles
Most recent articles on Cardiac Resynchronization Therapy Most cited articles on Cardiac Resynchronization Therapy Review articles on Cardiac Resynchronization Therapy Articles on Cardiac Resynchronization Therapy in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Cardiac Resynchronization Therapy Images of Cardiac Resynchronization Therapy Photos of Cardiac Resynchronization Therapy Podcasts & MP3s on Cardiac Resynchronization Therapy Videos on Cardiac Resynchronization Therapy
Evidence Based Medicine
Cochrane Collaboration on Cardiac Resynchronization Therapy Bandolier on Cardiac Resynchronization Therapy TRIP on Cardiac Resynchronization Therapy
Clinical Trials
Ongoing Trials on Cardiac Resynchronization Therapy at Clinical Trials.gov Trial results on Cardiac Resynchronization Therapy Clinical Trials on Cardiac Resynchronization Therapy at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Cardiac Resynchronization Therapy NICE Guidance on Cardiac Resynchronization Therapy NHS PRODIGY Guidance FDA on Cardiac Resynchronization Therapy CDC on Cardiac Resynchronization Therapy
Books
Books on Cardiac Resynchronization Therapy
News
Cardiac Resynchronization Therapy in the news Be alerted to news on Cardiac Resynchronization Therapy News trends on Cardiac Resynchronization Therapy
Commentary
Blogs on Cardiac Resynchronization Therapy
Definitions
Definitions of Cardiac Resynchronization Therapy
Patient Resources / Community
Patient resources on Cardiac Resynchronization Therapy Discussion groups on Cardiac Resynchronization Therapy Patient Handouts on Cardiac Resynchronization Therapy Directions to Hospitals Treating Cardiac Resynchronization Therapy Risk calculators and risk factors for Cardiac Resynchronization Therapy
Healthcare Provider Resources
Symptoms of Cardiac Resynchronization Therapy Causes & Risk Factors for Cardiac Resynchronization Therapy Diagnostic studies for Cardiac Resynchronization Therapy Treatment of Cardiac Resynchronization Therapy
Continuing Medical Education (CME)
CME Programs on Cardiac Resynchronization Therapy
International
Cardiac Resynchronization Therapy en Espanol Cardiac Resynchronization Therapy en Francais
Business
Cardiac Resynchronization Therapy in the Marketplace Patents on Cardiac Resynchronization Therapy
Experimental / Informatics
List of terms related to Cardiac Resynchronization Therapy

Cardiology Network
Discuss Cardiac Resynchronization Therapy further in the WikiDoc Cardiology Network
Adult Congenital
Biomarkers
Cardiac Rehabilitation
Congestive Heart Failure
CT Angiography
Echocardiography
Electrophysiology
Cardiology General
Genetics
Health Economics
Hypertension
Interventional Cardiology
MRI
Nuclear Cardiology
Peripheral Arterial Disease
Prevention
Public Policy
Pulmonary Embolism
Stable Angina
Valvular Heart Disease
Vascular Medicine

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Associate Editor: Cafer Zorkun, M.D., Ph.D. [2] Assistant Editor: Atif Mohammad, MD

Introduction

Cardiac resynchronization therapy is a relatively new mode of therapeutic modality currently being used particularly in patients with advanced heart failure.Bi-ventricular pacing or pacing one of the ventricles with bundle branch block is referred to as Cardiac Resynchronization Therapy.

Currently CRT has been approved in patients with advanced HF patients benefit from simultaneous pacing of both ventricles (biventricular or BiV pacing) or of one ventricle in patients with bundle branch block. This approach is referred to as cardiac resynchronization therapy (CRT) . CRT can be achieved with a device designed only for pacing or can be incorporated into a combination device with an ICD.

Cardiac Resynchronization therapy has been approved for patients with advanced heart failure NYHA class III,IIV or patients with LVEF <35% and with QRS delay >120 ms.It has gain FDA approval for patients with NYHA class I OR II heart failure in the setting of QRS delay.

Mechanism of Benefit

CRT has been known to benefit patients with left ventricular dyssynchrony.The mechanism is till unclear but it is known to improve contractile performance of cardiac chambers and hence result in reverse remodeling improving functional capacity and decreasing clinical outcomes of mortality and repeat hospitalizations.Basically, CRT causes improved cardiac myocyte depolarization as a result of cardiac resynchronization which improves cardiac systolic function causing contraction of the left ventricle and thus reducing wall stress and mitral regurgitation.This also improves ventricular remodeling .

Improved contractility of LV in patients with HF associated with IVCD or LBBB is known to reduce myocardial energy demands and oxygen consumption.

CRT has shown to cause reverse ventricular remodeling.A study conducted in Hong Kong showed long term clinical improvement in patients treated with CRT. But it is still not clear whether,clinical improvement and ventricular remodeling correlate with each other or ventricular remodeling is necessary for reduction in clinical signs and symptoms.

Please Take Over This Page and Apply to be Editor-In-Chief for this topic: There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us [3] to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch.