Patent ductus arteriosus pathophysiology

WikiDoc Resources for Patent ductus arteriosus pathophysiology
Articles
Most recent articles on Patent ductus arteriosus pathophysiology Most cited articles on Patent ductus arteriosus pathophysiology Review articles on Patent ductus arteriosus pathophysiology Articles on Patent ductus arteriosus pathophysiology in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Patent ductus arteriosus pathophysiology Images of Patent ductus arteriosus pathophysiology Photos of Patent ductus arteriosus pathophysiology Podcasts & MP3s on Patent ductus arteriosus pathophysiology Videos on Patent ductus arteriosus pathophysiology
Evidence Based Medicine
Cochrane Collaboration on Patent ductus arteriosus pathophysiology Bandolier on Patent ductus arteriosus pathophysiology TRIP on Patent ductus arteriosus pathophysiology
Clinical Trials
Ongoing Trials on Patent ductus arteriosus pathophysiology at Clinical Trials.gov Trial results on Patent ductus arteriosus pathophysiology Clinical Trials on Patent ductus arteriosus pathophysiology at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Patent ductus arteriosus pathophysiology NICE Guidance on Patent ductus arteriosus pathophysiology NHS PRODIGY Guidance FDA on Patent ductus arteriosus pathophysiology CDC on Patent ductus arteriosus pathophysiology
Books
Books on Patent ductus arteriosus pathophysiology
News
Patent ductus arteriosus pathophysiology in the news Be alerted to news on Patent ductus arteriosus pathophysiology News trends on Patent ductus arteriosus pathophysiology
Commentary
Blogs on Patent ductus arteriosus pathophysiology
Definitions
Definitions of Patent ductus arteriosus pathophysiology
Patient Resources / Community
Patient resources on Patent ductus arteriosus pathophysiology Discussion groups on Patent ductus arteriosus pathophysiology Patient Handouts on Patent ductus arteriosus pathophysiology Directions to Hospitals Treating Patent ductus arteriosus pathophysiology Risk calculators and risk factors for Patent ductus arteriosus pathophysiology
Healthcare Provider Resources
Symptoms of Patent ductus arteriosus pathophysiology Causes & Risk Factors for Patent ductus arteriosus pathophysiology Diagnostic studies for Patent ductus arteriosus pathophysiology Treatment of Patent ductus arteriosus pathophysiology
Continuing Medical Education (CME)
CME Programs on Patent ductus arteriosus pathophysiology
International
Patent ductus arteriosus pathophysiology en Espanol Patent ductus arteriosus pathophysiology en Francais
Business
Patent ductus arteriosus pathophysiology in the Marketplace Patents on Patent ductus arteriosus pathophysiology
Experimental / Informatics
List of terms related to Patent ductus arteriosus pathophysiology

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Associate Editors-In-Chief: Cafer Zorkun, M.D., Ph.D. [2]; Keri Shafer, M.D. [3]

Please Take Over This Page and Apply to be Editor-In-Chief for this topic: There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us [4] to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch.

Pathophysiology

Consequences depend on the size of the defect and the pulmonary vascular resistance (PVR).

Small PDA

1. Small left-to-right shunt (Qp/Qs < 1.5).
2. Normal ratio of pulmonary artery (PA) to systemic pressure.
3. Shunt throughout the cardiac cycle, continuous murmur.

Medium-sized PDA

1. Qp/Qs 1.5 to 2.0 yet small enough to offer some resistance to flow.
2. PA systolic to systemic pressures are < 0.5.
3. Unusual for this group to have markedly increased PVR.
4. Due to increased return to the left heart, there is volume overload of the left atrium (LA) and the left ventricle (LV).

Large PDA

1. Defect does not restrict flow.
2. There is pulmonary hypertension at near systemic pressures (PA systolic/systolic pressure is >0.5).
3. Because of the physiologic decrease in the PVR over the first three months of life there is a large left-to-right shunt with Qp/Qs > 2.
4. The large volume overload of the left ventricle may result in LV failure.
5. There is pulmonary hypertension.
6. There may be two courses:
   1. A decrease in the relative size of the ductus compared with other cardiovascular structures. This results in a medium-sized defect compared with the course expected for a medium-sized defect.
   2. The development of severe pulmonary vascular obstructive disease, can occur at any time from age 3 until early adulthood. The left-to-right shunt converts to a right-to-left shunt with cyanosis and disappearance of the continuous murmur.