Ebsteins anomaly of the tricuspid valve pathophysiology

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] and Claudia P. Hochberg, M.D. [2]

Associate Editor-In-Chief: Cafer Zorkun, M.D., Ph.D. [3]}; Keri Shafer, M.D. [4] Priyamvada Singh, MBBS [[5]]

Assistant Editor-In-Chief: Kristin Feeney, B.S. [[6]]

Pathophysiology

The pathophysiology of Ebstein's anomaly depends on the morphology of tricuspid valve and right ventricle.

• Tricuspid valve-
  • The anterior leaflet of the tricuspid valve are malformed i.e they are attached to tricuspid valve annulus or to the right ventricular endocardium
  • The septal and posterior leaflets are absent most of the times.
  • Due to these changes the tricuspid valve may becomes funnel-shaped

Right ventricle- The right ventricular changes are secondary to the malformed tricuspid valves. The right ventricle can thus be divided into two parts by the valve

• The downward extension of the tricuspid valve causes 'atrialization of the right ventricle'
• The small distal part, the right ventricle proper, thus is reduced in size and sometimes comprises only of the right outflow tract.