Basal-like carcinoma
Please Take Over This Page and Apply to be Editor-In-Chief for this topic: There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us [1] to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch.
Overview
The basal-like breast carcinoma is a newly proposed subtype of breast cancer defined by its gene expression and protein expression profile [1]. In the current WHO breast tumor classification, these tumors are classified as ductal carcinoma. They are high grade, "triple-negative" tumors, i.e. they express no estrogen receptor, progesterone receptor nor Her2/neu proteins.
Basal-like carcinomas tend to be more aggressive, with a poor prognosis. In the U.S., they are more frequent among black women, which may explain the higher mortality rate in this group.
References
- ↑ Phenotypic evaluation of the basal-like subtype of invasive breast carcinoma, Modern Pathology 19:264-271 (2006), via www.nature.com