Atrial septal defect risk factors
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Priyamvada Singh, M.B.B.S. [[2]]; Cafer Zorkun, M.D., Ph.D. [3]; Assistant Editor(s)-In-Chief: Kristin Feeney, B.S. [[4]]
Overview
The cause of atrial septal defects is not known. However, it has been found to occur with increased frequencies in patients with Down syndrome, thus suggesting some genetic association. As a parent, if you or a sibling of a child have a congenital heart defect, then you should consider genetic counseling.
Risk factors
Factors in the mother that may increase the risk of this condition include
- Generally, atrial septal defect is not known to be associated with any specific single gene defect, but some studies have shown possible genetic association in some cases, involving downs syndrome and deletions of chromosome 22q11.
- Age over 40
- Alcoholism [1].
- Diabetes
- Prenatal nutrition
- Rubella or other viral illness during pregnancy