Alteplase side effects

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

List of side effects

Cardiovascular

CNS

Dermatologic

GI

Genitourinary

Hypersensitivity

Miscellaneous

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Cardiovascular

• All strokes (2%);
• arrhythmia;
• AV block;
• cardiogenic shock;
• heart failure;
• cardiac arrest;
• recurrent ischemia;
• myocardial reinfarction;
• myocardial rupture;
• electromechanical dissociation;
• pericardial effusion;
• pericarditis;
• mitral regurgitation;
• cardiac tamponade;
• thromboembolism;
• pulmonary edema;
• hypotension;
• pulmonary re-embolization.

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Cathflo Activase

• Venous thrombosis;
• major hemorrhage;
• intracranial hemorrhage;
• pulmonary emboli;
• upper extremity deep vein thrombosis.

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CNS

• Cerebral edema;
• cerebral herniation;
• seizure.

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Dermatologic

• Ecchymosis (1%);
• injection-site hemorrhage.

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GI

• Bleeding (5%);
• nausea;
• vomiting.

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Genitourinary

• Bleeding (4%).

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Hypersensitivity

• Allergic-type reactions (e.g, anaphylactoid reactions, laryngeal edema, orolingual angioedema, rash, urticaria).

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Miscellaneous

• Fever;
• pleural effusion.

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Cathflo Activase

• Sepsis;
• death.

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Adapted from the FDA Package Insert.