Amlodipine/benazepril
Synonyms / Brand Names: Amlodipine Benzenesulfonate, Amlodipine Besilate, Amlodipine Free Base, Amlodipino, Amlodipinum,Amlocard, Amlodis, Amvaz, Coroval, Lipinox, Lotrel, benazepril, Benazepril HCl, Benazepril Hydrochloride, Benazeprilum, Briem, Cibacen, Cibacene
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Dosing and Administration
Treatment of hypertension
Amlodipine is an effective treatment of hypertension in once-daily doses
of 2.5-10 mg while benazepril is effective in doses of 10-80 mg. In clinical
trials of amlodipine/benazepril combination therapy using amlodipine
doses of 2.5-10 mg and benazepril doses of 10-20 mg, the antihypertensive
effects increased with increasing dose of amlodipine in all patient
groups, and the effects increased with increasing dose of benazepril in
nonblack groups. All patient groups benefited from the reduction in
amlodipine-induced edema
Dose Titration Guided by Clinical Effect
A patient whose blood pressure
is not adequately controlled with amlodipine (or another dihydropyridine)
alone or with benazepril (or another ACE inhibitor) alone may be
switched to combination therapy with Lotrel. The addition of benazepril to
a regimen of amlodipine should not be expected to provide additional
antihypertensive effect in African-Americans. However, all patient groups
benefit from the reduction in amlodipine-induced edema. Dosage must be
guided by clinical response; steady-state levels of benazepril and
amlodipine will be reached after approximately 2 and 7 days of dosing,
respectively.
FDA Package Insert Resources
Indications, Contraindications, Side Effects, Drug Interactions, etc.
Calculate Creatine Clearance
On line calculator of your patients Cr Cl by a variety of formulas.
Convert pounds to Kilograms
On line calculator of your patients weight in pounds to Kg for dosing estimates.
Publication Resources
Recent articles, WikiDoc State of the Art Review, Textbook Information
Trial Resources
Ongoing Trials, Trial Results
Guidelines & Evidence Based Medicine Resources
US National Guidelines, Cochrane Collaboration, etc.
Media Resources
Slides, Video, Images, MP3, Podcasts, etc.
Patient Resources
Discussion Groups, Handouts, Blogs, News, etc.
International Resources
en Español
FDA Package Insert Resources
Indications
Contraindications
Side Effects
Drug Interactions
Precautions
Overdose
Instructions for Administration
How Supplied
Pharmacokinetics and Molecular Data
FDA label
FDA on Amlodipine/benazepril
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Publication Resources
Most Recent Articles on Amlodipine/benazepril
Review Articles on Amlodipine/benazepril
Articles on Amlodipine/benazepril in N Eng J Med, Lancet, BMJ
WikiDoc State of the Art Review
Textbook Information on Amlodipine/benazepril
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Trial Resources
Ongoing Trials with Amlodipine/benazepril at Clinical Trials.gov
Trial Results with Amlodipine/benazepril
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Guidelines & Evidence Based Medicine Resources
US National Guidelines Clearinghouse on Amlodipine/benazepril
Cochrane Collaboration on Amlodipine/benazepril
Cost Effectiveness of Amlodipine/benazepril
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Media Resources
Powerpoint Slides on Amlodipine/benazepril
Images of Amlodipine/benazepril
Podcasts & MP3s on Amlodipine/benazepril
Videos on Amlodipine/benazepril
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Patient Resources
Patient Resources on Amlodipine/benazepril
Discussion Groups on Amlodipine/benazepril
Patient Handouts on Amlodipine/benazepril
Blogs on Amlodipine/benazepril
Amlodipine/benazepril in the News
Amlodipine/benazepril in the Marketplace
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International Resources
Amlodipine/benazepril en Español
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Adapted from the FDA Package Insert.