Mecamylamine

Mecamylamine

Clinical data
ATC code	C02BB01 (WHO)
Legal status
Legal status	In general: ℞ (Prescription only)
Pharmacokinetic data
Protein binding	40%
Identifiers
IUPAC name N,2,3,3-tetramethylnorbornan-2-amine
CAS Number	60-40-2 82924-03-6
PubChem CID	4032
DrugBank	APRD00458
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C11H21N
Molar mass	167.291 g/mol

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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Overview

Mecamylamine is a nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool.

Mecamylamine is also sometimes used as an anti-addictive drug to help people stop smoking tobacco, and is now more widely used for this application than it is for lowering blood pressure. This effect is thought to be due to it blocking α3β4 nicotinic receptors in the brain.