Metformin
Synonyms / Brand Names: Metformin HCL, metformin hydrochloride, Apo-Metformin, Fortamet, Gen-Metformin, Glucophage, Glucophage XR, Glycon, Novo-Metformin, Nu-Metformin, Riomet
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Dosing and Administration
GLUCOPHAGE
The usual starting dose of GLUCOPHAGE (metformin hydrochloride tablets) is 500
mg twice a day or 850 mg once a day, given with meals. Dosage increases should be made
in increments of 500 mg weekly or 850 mg every 2 weeks, up to a total of 2000 mg per
day, given in divided doses. Patients can also be titrated from 500 mg twice a day to 850
mg twice a day after 2 weeks. For those patients requiring additional glycemic control,
GLUCOPHAGE may be given to a maximum daily dose of 2550 mg per day. Doses
above 2000 mg may be better tolerated given three times a day with meals.
GLUCOPHAGE XR
The usual starting dose of GLUCOPHAGE XR (metformin hydrochloride extendedrelease
tablets) is 500 mg once daily with the evening meal. Dosage increases should be
made in increments of 500 mg weekly, up to a maximum of 2000 mg once daily with the
evening meal. If glycemic control is not achieved on GLUCOPHAGE XR 2000 mg once
daily, a trial of GLUCOPHAGE XR 1000 mg twice daily should be considered. If higher
doses of metformin are required, GLUCOPHAGE should be used at total daily doses up to
2550 mg administered in divided daily doses, as described above
FDA Package Insert Resources
Indications, Contraindications, Side Effects, Drug Interactions, etc.
Calculate Creatine Clearance
On line calculator of your patients Cr Cl by a variety of formulas.
Convert pounds to Kilograms
On line calculator of your patients weight in pounds to Kg for dosing estimates.
Publication Resources
Recent articles, WikiDoc State of the Art Review, Textbook Information
Trial Resources
Ongoing Trials, Trial Results
Guidelines & Evidence Based Medicine Resources
US National Guidelines, Cochrane Collaboration, etc.
Media Resources
Slides, Video, Images, MP3, Podcasts, etc.
Patient Resources
Discussion Groups, Handouts, Blogs, News, etc.
International Resources
en Español
FDA Package Insert Resources
Indications
Contraindications
Side Effects
Drug Interactions
Precautions
Overdose
Instructions for Administration
How Supplied
Pharmacokinetics and Molecular Data
FDA label
FDA on Metformin
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Publication Resources
Most Recent Articles on Metformin
Review Articles on Metformin
Articles on Metformin in N Eng J Med, Lancet, BMJ
WikiDoc State of the Art Review
Textbook Information on Metformin
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Trial Resources
Ongoing Trials with Metformin at Clinical Trials.gov
Trial Results with Metformin
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Guidelines & Evidence Based Medicine Resources
US National Guidelines Clearinghouse on Metformin
Cochrane Collaboration on Metformin
Cost Effectiveness of Metformin
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Media Resources
Powerpoint Slides on Metformin
Images of Metformin
Podcasts & MP3s on Metformin
Videos on Metformin
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Patient Resources
Patient Information from National Library of Medicine
Patient Resources on Metformin
Discussion Groups on Metformin
Patient Handouts on Metformin
Blogs on Metformin
Metformin in the News
Metformin in the Marketplace
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International Resources
Metformin en Español
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Adapted from the FDA Package Insert.