Mirtazapine

Synonyms / Brand Names: Mirtazapina, Mirtazapinum, Mirtazepine, Mepirzepine, Remeron, Remeron Soltab, Zispin, Remergil, Norset, Rexer, Remergon, Mirtabene, Avanza, Mirtazon, Axit, Mirtaz, Promyrtil

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Dosing and Administration

The recommended starting dose for Mirtazapine tablets USP is 15 mg/day, administered in a single dose, preferably in the evening prior to sleep. In the controlled clinical trials establishing the efficacy of Mirtazapine in the treatment of major depressive disorder, the effective dose range was generally 15 mg/day to 45 mg/day. While the relationship between dose and satisfactory response in the treatment of major depressive disorder for Mirtazapine has not been adequately explored, patients not responding to the initial 15 mg dose may benefit from dose increases up to a maximum of 45 mg/day. Mirtazapine has an elimination half-life of approximately 20 to 40 hours, therefore, dose changes should not be made at intervals of less than one to two weeks in order to allow sufficient time for evaluation of the therapeutic response to a given dose.

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