Spironolactone drug interactions
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Major Interactions
- Accupril
- Aceon
- Altace
- Aminosyn II 3.5%-Dextrose 25% Electrolytes Ca
- Aminosyn II 4.25%-Dextrose 20% Electrolyte Ca
- Aminosyn II 4.25%-Dextrose 25% Electrolyte Ca
- Aminosyn II with Electrolytes
- Aminosyn II with Electrolytes Sulfite-Free
- Aminosyn with Electrolytes
- Aminosyn with Electrolytes Sulfite-Free
- Atacand
- Avapro
- benazepril
- Benicar
- candesartan
- Capoten
- captopril
- Cena K
- Clinimix E Sulfite Free
- Cozaar
- Dextrose 10% and Electrolyte No. 48
- Diovan
- Ed K+10
- Effervescent Potassium
- enalapril
- enalaprilat
- eplerenone
- eprosartan
- Eskalith
- Eskalith-CR
- fosinopril
- Freamine III with Electrolytes
- Glu-K
- Inspra
- Ionosol B and 5% Dextrose
- Ionosol MB and 5% Dextrose
- Ionosol T and 5% Dextrose
- irbesartan
- Isolyte E
- Isolyte H and 5 % Dextrose
- Isolyte M and 5% Dextrose
- Isolyte P and 5% Dextrose
- Isolyte R and 5% Dextrose
- K + Potassium
- K+Care ET
- K-10
- K-8
- K-Dur 10
- K-Dur 20
- K-Effervescent
- K-Lor
- K-Norm
- K-Phos Original
- K-Sol
- K-Tab
- K-vescent
- K-Vescent (obsolete)
- K-Vescent (Potassium Chloride)
- Kaochlor
- Kaochlor S-F
- Kaon
- Kaon-CI
- Kaon-CL 10
- Kaon-CL 20%
- Kato
- Kay Ciel
- KCl
- KCl-20
- Klor-Con
- Klor-Con 10
- Klor-Con 8
- Klor-Con M10
- Klor-Con M15
- Klor-Con M20
- Klor-Con/25
- Klotrix
- lisinopril
- lithium
- lithium carbonate
- lithium carbonate extended release
- lithium citrate
- Lithobid
- Lithonate
- Lithotabs
- losartan
- Lotensin
- LVP solution with potassium
- Lysodren
- Mavik
- Micardis
- Micro-K
- Micro-K 10
- mitotane
- moexipril
- Monopril
- Neutra-Phos-K
- Normosol-M and 5% Dextrose
- olmesartan
- parenteral nutrition solution w/electrolytes
- PC-10
- Perchloracap
- perindopril
- Plasma-Lyte 56
- Plasma-Lyte and 5% Dextrose
- potassium acetate
- potassium acid phosphate
- potassium bicarbonate
- potassium chloride
- potassium chloride extended release
- potassium citrate
- potassium gluconate
- potassium guaiacolsulfonate
- potassium perchlorate
- potassium phosphate
- Prinivil
- Procalamine
- quinapril
- ramipril
- Rum-K
- Slow-K
- sodium biphosphate
- telmisartan
- Ten-K
- Teveten
- tizanidine
- trandolapril
- Travasol with Electrolytes
- Travasol with Electrolytes Dual Chamber
- Travert 10% and Electrolyte No.2
- Travert 5% and Electrolyte No.2
- Twin-K
- Univasc
- Urocit-K
- valsartan
- Vasotec
- Zanaflex
- Zestril
Moderate Interactions
- 40 Winks
- A-Hydrocort
- A-Methapred
- Abilify
- Abilify Discmelt
- acebutolol
- Acetocot
- ACTH
- ACTH Gel
- ACTH-40 HP
- ACTH-80
- Acthar
- Acthar Gel H.P.
- Acthrel
- Actiq
- Actron
- Adapin
- Adbeon
- Adgan
- Adlone-40
- Adlone-80
- Adrenocot
- Adrenocot L.A.
- Advil
- Advil Childrens
- Advil Junior Strength
- Advil Liquigel
- Advil Migraine
- Advil Pediatric
- Aflaxen
- Akbeta
- alcohol
- alcohol
- ethyl
- aldesleukin
- Aler-Dryl
- Aler-Tab
- Aleve
- Aleve Caplet
- Aleve Easy Open Arthritis
- Aleve Gelcap
- Alfenta
- alfentanil
- All Day Allergy
- Allergia-C
- Allermax
- alprazolam
- alprazolam extended release
- Altaryl
- Ambien
- Ambien CR
- amifostine
- amitriptyline
- amoxapine
- Anafranil
- Anaprox
- Anaprox-DS
- Anergan 50
- Ansaid
- Antiflex
- Antinaus 50
- APO-Go
- APO-Go Pen
- Apokyn
- apomorphine
- Aquachloral Supprettes
- aripiprazole
- Aristocort
- Aristocort For Injection
- Aristocort Forte
- Aristopak
- Aristospan Injection
- Asendin
- Astramorph PF
- Atarax
- atenolol
- Ativan
- Avinza
- Azmacort
- baclofen
- Banaril
- Banflex
- Banophen
- Beldin
- Belix
- Ben-Tann
- Benadryl
- Benadryl Allergy
- Benadryl Child Dye Free
- Benadryl Childrens Allergy Fastmelt
- Benadryl DF
- Benadryl Dye Free Allergy
- Benadryl Ultratab
- Benahist-10
- Benahist-50
- Benoject-50
- Beta-Phos/AC
- Betagan
- Betagan C-Cap
- betamethasone
- betamethasone acet-betamethasone na phosphate
- betamethasone sodium phosphate
- Betapace
- Betapace AF
- Betapace AF(obsolete)
- betaxolol
- betaxolol ophthalmic
- Betimol
- Betoptic
- Betoptic S
- Bextra
- bisoprolol
- Blocadren
- bromfenac
- Bubbli-Pred
- Budeprion SR
- Budeprion XL
- budesonide
- Buprenex
- buprenorphine
- bupropion
- bupropion 24 hour extended release
- bupropion extended release
- Busodium
- buspar
- Buspar Dividose
- busPIRone
- butabarbital
- Butisol Sodium
- Bydramine
- Bystolic
- cabergoline
- Calm-Aid
- Camptosar
- Carbacot
- carbamazepine
- carbamazepine extended release
- Carbatrol
- carisoprodol
- carteolol ophthalmic
- carvedilol
- carvedilol extended release
- Cataflam
- Celebrex
- celecoxib
- Celestone
- Celestone Phosphate
- Celestone Soluspan
- Celexa
- Cell-U-Jec
- cetirizine
- Childrens Ibuprofen Berry
- chloral hydrate
- chlordiazepoxide
- chlorpromazine
- chlorpromazine extended release
- cholestyramine
- Cholestyramine Light
- citalopram
- Clinacort
- Clinalog
- Clinoril
- clomipramine
- clonazepam
- Clopine
- clorazepate
- clorazepate extended release
- clozapine
- Clozapine Synthon
- Clozaril
- codeine
- codeine phosphate
- codeine sulfate
- Colocort
- Compazine
- Compazine Spansule
- Compoz Nighttime Sleep Aid
- Compro
- Coreg
- Coreg CR
- Corgard
- Corlopam
- Cort-K
- Cortastat
- Cortastat 10
- Cortastat LA
- Cortef
- Cortenema
- corticorelin
- corticotropin
- Cortifoam
- cortisone
- Cortone Acetate
- Cortrosyn
- cosyntropin
- Cotolone
- cyclosporine
- Dalalone
- Dalalone D.P.
- Dalalone L.A.
- Dalmane
- Darvon
- Darvon-N
- Daypro
- Dazidox
- De-Sone LA
- Decadron
- Decadron 5-12 Pak
- Decadron Phosphate Injectable
- Decadron-LA
- Decaject
- Decaject L.A.
- Dehydrated Alcohol
- Deltasone
- Demerol HCl
- Denzapine
- Dep Medalone 80
- Depmedalone
- Depo-Medrol
- Depo-Predate (obsolete)
- Depoject-80
- Depopred
- Desyrel
- Desyrel Dividose
- Dexacen-4
- Dexacort Phosphate in Respihaler
- Dexacort-LA
- Dexacorten
- dexamethasone
- dexamethasone acetate
- Dexamethasone Intensol
- dexamethasone sodium phosphate
- Dexasone
- Dexasone LA
- Dexone
- Dexone LA
- Dexpak Jr. Taperpak
- Dexpak Taperpak
- Diastat
- Diastat AcuDial
- Diastat Pediatric
- diazepam
- diclofenac
- diclofenac potassium
- diclofenac sodium
- diclofenac sodium extended release
- diflunisal
- dihydrocodeine
- Dilaudid
- Dilaudid-5
- Dilaudid-HP
- Diphedryl
- Diphen
- Diphen AF
- Diphen Cough
- Diphenadryl
- Diphendryl
- Diphenhist
- diphenhydramine
- diphenhydramine citrate
- diphenhydramine tannate
- Diphenmax
- Diphenydramine Quick Melt
- Diphenyl
- Diphenylin
- Diskets
- Dizac
- Dolobid
- Dolophine
- Doloral
- Doloral Sirop
- Dopar
- Dostinex
- doxepin
- doxepin topical
- DPH
- drospirenone
- DurAct
- Duragesic
- Duragesic-100
- Duragesic-12
- Duragesic-25
- Duragesic-50
- Duragesic-75
- Duralone
- Duramorph PF
- Dytan
- Dytuss
- EC-Naprosyn
- Effexor
- Effexor XR
- Elavil
- Endep
- Endocodone
- Entocort
- Entocort EC
- Epitol
- epoprostenol
- Equanil
- Equetro
- escitalopram
- ETH-Oxydose
- ethanol
- Ethyl Alcohol
- Ethyol
- etodolac
- etodolac extended release
- FazaClo
- Feldene
- fenoldopam
- fenoprofen
- fentanyl
- Fentora
- Flexoject
- Flexon
- Flo-Pred
- Flolan
- Florinef Acetate
- fludrocortisone
- fluoxetine
- fluoxetine extended release
- fluphenazine
- fluphenazine decanoate
- fluphenazine enanthate
- fluphenazine hydrochloride
- flurazepam
- flurbiprofen
- fluvoxamine
- fluvoxamine extended release
- Fortamet
- Genahist
- Gengraf
- Genpril
- Geodon
- Glucophage
- Glucophage XR
- Glumetza
- Haldol
- Haldol Decanoate
- haloperidol
- haloperidol decanoate
- Haltran
- Hexadrol
- Hexadrol Phosphate
- Hydeltra-T.B.A.
- Hydeltrasol
- Hydramine
- Hydramine Compound
- Hydramine Cough Syrup
- hydrocortisone
- hydrocortisone acetate
- hydrocortisone cypionate
- hydrocortisone hemisuccinate
- hydrocortisone sodium phosphate
- Hydrocortisone Sodium Succinate
- Hydrocortone
- Hydrocortone Phosphate
- Hydromorph Contin
- hydromorphone
- hydromorphone extended release
- Hydrostat IR
- hydroxyzine
- hydroxyzine hydrochloride
- hydroxyzine pamoate
- Hyrexin
- Hyzine
- Ibu
- IBU-200
- Ibu-4
- Ibu-6
- Ibu-8
- Ibu-Tab
- ibuprofen
- Ibuprofen PMR
- iloprost
- imipramine
- imipramine pamoate
- Inderal
- Inderal LA
- Indocin
- Indocin SR
- indomethacin
- indomethacin extended release
- Infumorph
- InnoPran XL
- Invega
- Ionsys
- irinotecan
- Istalol
- Kadian
- Ken-Jec 40
- Kenaject-40
- Kenalog-10
- Kenalog-40
- Kerlone
- ketoprofen
- ketoprofen extended release
- ketorolac
- Key-Pred
- Key-Pred SP
- Klonopin
- Klonopin Wafer
- labetalol
- Larodopa
- Leader Naproxen Sodium
- Levobunolol
- levobunolol ophthalmic
- levocetirizine
- levodopa
- Levrix
- Lexapro
- Librium
- Lioresal
- Lioresal Intrathecal
- Liquid Pred
- Lodine
- Lodine XL
- Lopressor
- lorazepam
- loxapine
- Loxitane
- Loxitane C
- Loxitane IM
- Ludiomil
- Luminal
- Luvox
- Luvox CR
- M-Eslon
- M-Oxy
- M-Prednisolone
- M. O. S.
- maprotiline
- maraviroc
- MB-TAB
- meclofenamate
- Meclomen
- Med-Jec-40
- Medicort
- Medidex
- Medidex LA
- Medipred
- Medralone
- Medralone 40
- Medralone 80
- Medrol
- Medrol Dosepak
- mefenamic acid
- Mellaril
- Mellaril-S
- meloxicam
- Menadol
- meperidine
- meprobamate
- metformin
- metformin extended release
- Methacort 40
- Methacort 80
- methadone
- Methadose
- methdilazine
- methocarbamol
- Methylcotol
- Methylcotolone
- Methylpred DP
- methylprednisolone
- methylprednisolone acetate
- methylprednisolone dose pack
- methylprednisolone sodium succinate
- Meticorten
- metipranolol ophthalmic
- metoprolol
- metoprolol extended release
- metoprolol succinate
- Metoprolol Succinate ER
- metoprolol tartrate
- midazolam
- Midol Extended Relief
- Midol IB
- Midol Maximum Strength Cramp Formula
- Millipred
- Miltown
- Mio-Rel
- mirtazapine
- Mitran
- Mobic
- morphine
- morphine 24 hour extended release
- morphine extended release
- Morphine IR
- Morphine LP Epidural
- morphine preservative-free
- Morphine Rapi-Ject
- Morphitec
- Motrin
- Motrin Childrens
- Motrin IB
- Motrin Infant Drops
- Motrin Junior Strength
- Motrin Migraine Pain
- MS
- MS Contin
- MS/S
- MSIR
- Myolin
- nabumetone
- nadolol
- nalbuphine
- Nalfon
- Naprelan '375'
- Naprelan '500'
- Naprosyn
- naproxen
- naproxen sodium
- Naproxen Sodium DS
- naproxen sodium extended release
- nebivolol
- nefazodone
- NeoProfen
- Neoral
- Nervine
- Nightime Sleepaid
- Niravam
- Norflex
- Norflex Injectable
- Normodyne
- Nu-Med
- Nubain
- Nuprin
- Nytol Caplet
- Ocupress
- olanzapine
- OMS
- opium
- Opium Deodorized
- OptiPranolol
- Oramorph SR
- Orapred
- Orapred ODT
- Orasone
- Orfro
- Ormazine
- orphenadrine
- orphenadrine extended release
- Orphenate
- Orudis
- Orudis KT
- Oruvail
- oxaprozin
- oxazepam
- oxycodone
- oxycodone extended release
- OxyContin
- Oxyfast
- OxyIR
- paliperidone
- Palladone
- Palladone SR
- Paral
- paraldehyde
- Pardryl
- Paregoric
- paroxetine
- paroxetine extended release
- paroxetine mesylate
- Paxil
- Paxil CR
- Pediacare Fever
- Pediapred
- Pentazine
- pentazocine
- Percolone
- Permitil
- perphenazine
- Pexeva
- Phenadoz
- Phenazine 50
- Phenergan
- Phenergan Fortis
- phenobarbital
- Phenoject-50
- phenylbutazone
- pindolol
- piroxicam
- Ponstel
- PP-Cap
- Pred-Ject-50
- Predacort 50
- Predacorten
- Predaject-50
- Predalone 50
- Predate-50
- Predcor
- Predicort RP
- Predicort-50
- Prednicen-M
- Prednicot
- prednisolone
- prednisolone acetate
- prednisolone sodium phosphate
- prednisolone tebutate
- prednisone
- Prelone
- Prevalite
- Pri-Cortin 50
- Primethasone
- Primsol
- Pro-Med
- prochlorperazine
- prochlorperazine extended release
- Procot
- Proleukin
- Prolixin
- Prolixin Decanoate
- Prolixin Enanthate
- Proloprim
- Promacot
- promazine
- promethazine
- Promethegan
- propoxyphene
- propoxyphene hydrochloride
- propoxyphene napsylate
- propranolol
- propranolol extended release
- Prorex
- prostacyclin
- Prozac
- Prozac Weekly
- Prudoxin
- Pulmicort Flexhaler
- Pulmicort Nebuamp
- Pulmicort Respules
- Pulmicort Turbuhaler
- Q-Dryl
- Q-Dryl A/F
- Q-Profen
- Quenalin
- Questran
- Questran Light
- quetiapine
- quetiapine extended release
- Rapiflux
- Relafen
- Remeron
- Remeron SolTab
- Remodulin
- Rescudose
- Restoril
- Rezine
- Riomet
- Risperdal
- Risperdal Consta
- Risperdal M-Tab
- risperidone
- RMS
- Robaxin
- Robaxin-750
- rofecoxib
- Roxanol
- Roxanol 100
- Roxanol-T
- Roxicodone
- Roxicodone Intensol
- Rufen
- Saleto-200
- Saleto-400
- Saleto-600
- Saleto-800
- Sandimmune
- Sarafem
- Scot-Tussin Allergy Relief Formula
- secobarbital
- Seconal Sodium
- Sectral
- Selestoject
- Selfemra
- Selzentry
- Serax
- Seroquel
- Seroquel XR
- sertraline
- Serzone
- Siladryl
- Siladryl DAS
- Siladyl SA
- Silphen Cough
- Simply Sleep
- Sinequan
- Skelex
- Sleep Tab II
- Sleep Tabs
- Sleep-ettes
- Sleep-Eze-3
- Sleepinal
- Solfoton
- Solu-Cortef
- Solu-Medrol
- Solurex
- Solurex LA
- Soma
- Sominex
- Sominex Maximum Strength Caplet
- Somnicaps
- Somnote
- Sonata
- Sorine
- sotalol
- Sotalol Hydrochloride AF
- Sotalol Hydrochloride AF(obsolete)
- Sparine
- Statex
- Stelazine
- Sterapred
- Sterapred DS
- Sublimaze
- Subutex
- sulindac
- Surmontil
- TAC 3
- Tacaryl
- Talwin Lactate
- Tegretol
- Tegretol XR
- temazepam
- Tenormin
- Theraflu Thin Strips Multi Symptom
- thioridazine
- Thorazine
- timolol
- timolol hemihydrate ophthalmic
- timolol ophthalmic
- timolol ophthalmic long-acting
- Timoptic Ocudose
- Timoptic Ocumeter
- Timoptic Ocumeter Plus
- Timoptic-XE
- TMP
- Tofranil
- Tofranil-PM
- Tolectin
- Tolectin 600
- Tolectin DS
- tolmetin
- Toprol-XL
- Toradol
- Toradol IM
- Toradol IV/IM
- Total Allergy
- Tramacort-D
- Trandate
- Tranxene SD
- Tranxene T-Tab
- trazodone
- treprostinil
- Triam-A
- Triam-Forte
- triamcinolone
- triamcinolone acetonide
- triamcinolone diacetate
- triamcinolone hexacetonide
- Triamcot
- Triaminic Thin Strips Cough & Runny Nose
- Triamonide 40
- trifluoperazine
- Trilafon
- Trilog
- Trilone
- trimethoprim
- trimipramine
- Trimpex
- Tristoject
- Trux-adryl
- Tusstat
- Twilite
- U-Tri-Lone
- Uni-Tann
- Unisom Sleepgels Maximum Strength
- Uprima
- V-Gan-25
- V-Gan-50
- valdecoxib
- Valium
- Valrelease
- Valu-Dryl
- Vanadom
- Vanatrip
- venlafaxine
- venlafaxine extended release
- Ventavis
- Versed
- Vioxx
- Visken
- Vistacon
- Vistacot
- Vistaject-50
- Vistaril
- Vistaril IM
- Vistazine
- Vistazine 50
- Voltaren
- Voltaren-XR
- Wellbutrin
- Wellbutrin SR
- Wellbutrin XL
- Xanax
- Xanax XR
- Xyzal
- Xyzall
- zaleplon
- Zaponex
- Zebeta
- Zetran
- ziprasidone
- Zoloft
- zolpidem
- zolpidem extended release
- Zonalon
- Zyban
- Zyban Advantage Pack
- Zyprexa
- Zyprexa Zydis
- Zyrtec
- Zyrtec Hives
Minor Interactions
- Acetylsalicylic Acid
- Acuprin 81
- Adoxa
- Adoxa CK
- Adoxa TT
- Ala-Tet
- Alodox
- Amigesic
- Anaflex
- anisindione
- apraclonidine ophthalmic
- Argesic-SA
- Arthritis Pain
- Arthropan
- ASA
- Ascriptin Enteric
- Aspergum Cherry
- Aspergum Orginal
- Aspir-Low
- aspirin
- aspirin extended release
- Aspirin Lite Coat
- Aspirin Litecoat
- Aspirin Low Strength
- Aspirtab
- Atapryl
- Azilect
- Bayer Aspirin
- Bayer Aspirin Regimen
- Bayer Aspirin Sugar Free
- Bayer Aspirin with Calcium
- Bayer Childrens Aspirin
- Bayer Low Strength
- Bayer Plus
- Bayer Select Backache Pain Formula
- Bismarex
- Bismatrol
- Bismatrol Maximum Strength
- bismuth subsalicylate
- Brodspec
- Buffered Aspirin
- Bufferin
- Bufferin Arthritis Strength
- Bufferin Extra Strength
- Buffex
- Carbex
- Cardoxin
- Childrens Kaopectate
- choline salicylate
- Cialis
- Coumadin
- Declomycin
- demeclocycline
- dicumarol
- Digitek
- digitoxin
- digoxin
- digoxin capsule
- Disalcid
- Doans Pills
- Doans Pills Extra Strength
- Doryx
- Doxy Lemmon
- Doxy-Caps
- Doxy-D
- doxycycline
- doxycycline hyclate
- doxycycline monohydrate
- Dynacin
- Easprin
- Ecotrin
- Ecotrin Adult Low Strength
- Ecotrin Maximum Strength
- Eldepryl
- Empirin
- Emsam
- Emtet-500
- Entaprin
- Entercote
- Extra Strength Bayer
- Fasprin
- furazolidone
- Furoxone
- Genacote
- Gennin-FC
- Genprin
- glycyrrhiza
- Halfprin
- Iopidine
- isocarboxazid
- Jantoven
- Jumex
- K-Pek
- Kao-Tin Bismuth Subsalicylate Formula
- Kaopectate
- Kaopectate Anti-Diarrheal Upset Stomach Reliever
- Kaopectate Extra Strength
- Kapectolin (New Formula)
- Lanoxicaps
- Lanoxin
- licorice
- linezolid
- Litecoat Aspirin
- Low Dose ASA
- Maalox Total Stomach Relief
- Magan
- magnesium salicylate
- Marplan
- Marthritic
- Matulane
- Maximum Strength Stress
- Minitabs
- Minocin
- Minocin PAC
- minocycline
- minocycline extended release
- Miradon
- Mobidin
- Mono-Gesic
- Monodox
- MST
- Myrac
- Nardil
- Norwich Aspirin
- Nuprin Backache Caplet
- Oracea
- Oraxyl
- oxytetracycline
- Panmycin
- Parnate
- Peptic Relief
- Pepto-Bismol
- Pepto-Bismol Maximum Strength
- Periostat
- phenelzine
- phenyl salicylate
- Pink Bismuth
- procarbazine
- rasagiline
- Rexolate
- Robitet 500
- Salflex
- salicylamide
- salsalate
- Salsitab
- selegiline
- Selgene
- Sloprin
- sodium salicylate
- sodium thiosalicylate
- Solodyn
- St. Joseph Aspirin
- St. Joseph Aspirin Adult Chewable
- St. Joseph Aspirin Adult EC
- Stanback Analgesic
- Stress Maximum Strength
- Sumycin
- tadalafil
- Terramycin
- Tetracap
- Tetracon
- tetracycline
- Therapy Bayer
- tranylcypromine
- Tri-Buffered Aspirin
- Tusal
- Vectrin
- Vibra-Tabs
- Vibramycin
- Vibramycin Calcium
- Vibramycin Hyclate
- Vibramycin Monohydrate
- warfarin
- YSP Aspirin
- Zelapar
- Zero-Order Release
- Zorprin
- Zyvox
Adapted from the FDA Package Insert.