Methoxyflurane

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Methoxyflurane
File:Methoxyflurane.svg
Clinical data
Routes of
administration
Inhalation
ATC code
Identifiers
CAS Number
PubChem CID
DrugBank
E number{{#property:P628}}
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Chemical and physical data
FormulaC3H4Cl2F2O
Molar mass164.965 g/mol

Methoxyflurane (C3H4Cl2F2O) is an inhalational anaesthetic used in the 1960s, but withdrawn because of detrimental effects on the kidneys. This was due to fluoride ions being produced by its metabolism in the kidney. Its minimum alveolar concentration (MAC) is 0.2, hence it is extremely potent. It has a high lipid solubility (oil:gas coefficient around 950) giving it a very slow onset/offset, thus undesirable for anesthetic purposes.

Methoxyflurane is used extensively in Australian ambulance services, and in St John Ambulance as an emergency analgesic.

External links

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