Diacerein

Diacerein

File:Diacerein.svg
Clinical data
Synonyms	Diacetylrhein, diacerhein
Pregnancy category	Lacking information
Routes of administration	Oral
ATC code	M01AX21 (WHO)
Pharmacokinetic data
Protein binding	99%
Metabolism	Hepatic: deacetylation to rhein, later glucuronidation and sulfate conjugation
Elimination half-life	4 to 5 hours
Excretion	Renal (30%)
Identifiers
IUPAC name 4,5-diacetyloxy-9,10-dioxo-anthracene-2- carboxylic acid
CAS Number	13739-02-1
PubChem CID	26248
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C19H12O8
Molar mass	368.294 g/mol

Diacerein (INN), also known as diacetylrhein, is a drug used in the treatment of osteoarthritis. It works by inhibiting interleukin-1.

A 2005 Cochrane review found diacerein to be slightly, but significantly, more effective than placebo in controlling the pain of osteoarthritis.

Side effects

The most common side effects of diacerein treatment are gastrointestinal, such as diarrhea.