Nordazepam

Nordazepam

File:Nordazepam.svg
Clinical data
Pregnancy category	?
Routes of administration	Oral
ATC code	N05BA16 (WHO)
Legal status
Legal status	Schedule IV(US)
Pharmacokinetic data
Bioavailability	?
Metabolism	Hepatic
Elimination half-life	50-120 hours
Excretion	Renal
Identifiers
IUPAC name 9-chloro-6-phenyl- 2,5-diazabicyclo[5.4.0]undeca- 5,8,10,12-tetraen-3-one
CAS Number	1088-11-5
PubChem CID	2997
DrugBank	none
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C15H11ClN2O
Molar mass	270.71

Nordazepam (marketed under brand names Stilny®, Madar®, Vegesan®, and Calmday®), also known as nordiazepam and desmethyldiazepam, is a 1,4-benzodiazepine derivative. Like other benzodiazepine derivatives, it has anticonvulsant, anxiolytic, muscle relaxant and sedative properties. However, it is used primarily in the treatment of anxiety. It is an active metabolite of diazepam, chlordiazepoxide, clorazepate, prazepam, and medazepam.

Side effects

Common side effects of nordazepam include somnolence, which is more common in elderly patients and/or people on high dose regimens. Hypotonia, which is much less common, is also associated with high doses and/or old age.

Interactions

Benzodiazepines including N-desmethyldiazepam (nordazepam) may inhibit the glucuronidation of morphine leading to increased levels of and prolongation of the effects of morphine.

Abuse

Nordazepam and other sedative hypnotic drugs are detected frequently in cases of people suspected of driving under the influence of drugs. Other benzodiazepines and zolpidem and zopiclone are also found in high numbers of suspected drugged drivers. Many drivers have blood levels far exceeding the therapeutic dose range suggesting a high degree of abuse potential for benzodiazepines and zolpidem and zopiclone.

External links

• Inchem - Nordazepam

References

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