Azelastine (nasal)

Azelastine (nasal)

Clinical data
Pregnancy category	US: C (Risk not ruled out)
Routes of administration	intranasal, ocular
ATC code	R01AC03 (WHO) R06AX19 (WHO), S01GX07 (WHO)
Pharmacokinetic data
Bioavailability	40% (intranasal)
Elimination half-life	22 hours
Identifiers
IUPAC name 4-[(4-chlorophenyl)methyl]-2- (1-methylazepan-4-yl)-phthalazin-1-one
CAS Number	58581-89-8
PubChem CID	2267
DrugBank	APRD00813
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C22H24ClN3O
Molar mass	381.898 g/mol

Azelastine is an antihistamine and mast cell stabilizer available as a nasal spray (Astelin®) for hay fever and as eye drops (Optivar®) for allergic conjunctivitis.

Side effects

Nasal spray

Side effects of azelastine nasal spray vary somewhat depending on the condition being treated. The most common side effects include bitter taste, headache, rhinitis, nose bleed, and somnolence. Adults being treated for vasomotor rhinitis may also experience dysesthesia and sinusitis. Additional side effects experienced by adults being treated for seasonal allergies include nasal burning, pharyngitis, dry mouth, paroxysmal sneezing, nausea, fatigue, dizziness, and weight gain.

External links

• Official Astelin Website
• Official Optivar Website
• Manufacturer's Website