Lofexidine

Lofexidine
	File:Lofexidine structure.png
Clinical data
Routes of; administration	Oral
ATC code	N07BC04 (WHO) ;
Legal status
Legal status	UK: POM (Prescription only) ;
Pharmacokinetic data
Bioavailability	>90%
Protein binding	80–90%
Metabolism	Hepatic glucuronidation
Elimination half-life	11 hours
Excretion	Renal
Identifiers
	IUPAC name 2-[1-(2,6-dichlorophenoxy)ethyl]-4,5-dihydro-1H-imidazole;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C11H12Cl2N2O
Molar mass	259.131 g/mol

Lofexidine is an alpha₂-adrenergic receptor agonist, can be used as a short acting (short half life) anti-hypertensive, but mostly used to help with relief from symptoms of heroin or opiate withdrawal in opiate dependency. Used primarily in the United Kingdom [1]. See also clonidine.

v t e Antihypertensives (C02) and diuretics (C03)
Sympatholytic agents	Template:Navbox subgroup
Vasodilators	Diazoxide • hydrazinophthalazine (Hydralazine, Dihydralazine, Endralazine, Cadralazine) • Minoxidil • Nitroprusside • Phentolamine
Other antihypertensives	serotonin antagonist (Ketanserin) • endothelin receptor antagonist (Bosentan, Ambrisentan, Sitaxsentan) • MAOI (Pargyline) • THI (Metirosine)
Diuretics	Template:Navbox subgroup

Clinical data
File:Lofexidine structure.png
Routes of administration	Oral
ATC code	N07BC04 (WHO)
Legal status
Legal status	UK: POM (Prescription only)
Pharmacokinetic data
Bioavailability	>90%
Protein binding	80–90%
Metabolism	Hepatic glucuronidation
Elimination half-life	11 hours
Excretion	Renal
Identifiers
IUPAC name 2-[1-(2,6-dichlorophenoxy)ethyl]-4,5-dihydro-1H-imidazole
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C₁₁H₁₂Cl₂N₂O
Molar mass	259.131 g/mol

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