Aphidicolin
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Aphidicolin is defined as a tetracyclic diterpene antibiotic with antiviral and antimitotical properties. Aphidicolin is a reversible inhibitor of eukaryotic nuclear DNA replication. It blocks the cell cycle at early S-phase. It is a specific inhibitor of DNA polymerase A,D in eukaryotic cells and in some viruses and an Apoptosis inducer in HeLa cells.
Further reading
Expression of aphidicolin-induced fragile sites and their relationship between genetic susceptibility in breast cancer, ovarian cancer, and non-small-cell lung cancer patients
External links
|
WikiDoc Resources for Aphidicolin |
|
Articles |
|---|
|
Most recent articles on Aphidicolin Most cited articles on Aphidicolin |
|
Media |
|
Powerpoint slides on Aphidicolin |
|
Evidence Based Medicine |
|
Clinical Trials |
|
Ongoing Trials on Aphidicolin at Clinical Trials.gov Clinical Trials on Aphidicolin at Google
|
|
Guidelines / Policies / Govt |
|
US National Guidelines Clearinghouse on Aphidicolin
|
|
Books |
|
News |
|
Commentary |
|
Definitions |
|
Patient Resources / Community |
|
Patient resources on Aphidicolin Discussion groups on Aphidicolin Patient Handouts on Aphidicolin Directions to Hospitals Treating Aphidicolin Risk calculators and risk factors for Aphidicolin
|
|
Healthcare Provider Resources |
|
Causes & Risk Factors for Aphidicolin |
|
Continuing Medical Education (CME) |
|
International |
|
|
|
Business |
|
Experimental / Informatics |