Calicheamicin

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Calicheamicin is an antibiotic derived from organism Micromonospora echinospora. It was isolated originally from a rock collected in Waco, Texas by a hiking Scripps Institute chemist.

It is highly toxic but has found pharmacological use as a conjugate in antibody cancer therapeutics (e.g. Gemtuzumab).

References

• http://www.scripps.edu/newsandviews/e_20010226/nicolaou3.html
• J Antibiot (Tokyo). 1989 Jul;42(7):1070-87.

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