Neocarzinostatin

WikiDoc Resources for Neocarzinostatin
Articles
Most recent articles on Neocarzinostatin Most cited articles on Neocarzinostatin Review articles on Neocarzinostatin Articles on Neocarzinostatin in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Neocarzinostatin Images of Neocarzinostatin Photos of Neocarzinostatin Podcasts & MP3s on Neocarzinostatin Videos on Neocarzinostatin
Evidence Based Medicine
Cochrane Collaboration on Neocarzinostatin Bandolier on Neocarzinostatin TRIP on Neocarzinostatin
Clinical Trials
Ongoing Trials on Neocarzinostatin at Clinical Trials.gov Trial results on Neocarzinostatin Clinical Trials on Neocarzinostatin at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Neocarzinostatin NICE Guidance on Neocarzinostatin NHS PRODIGY Guidance FDA on Neocarzinostatin CDC on Neocarzinostatin
Books
Books on Neocarzinostatin
News
Neocarzinostatin in the news Be alerted to news on Neocarzinostatin News trends on Neocarzinostatin
Commentary
Blogs on Neocarzinostatin
Definitions
Definitions of Neocarzinostatin
Patient Resources / Community
Patient resources on Neocarzinostatin Discussion groups on Neocarzinostatin Patient Handouts on Neocarzinostatin Directions to Hospitals Treating Neocarzinostatin Risk calculators and risk factors for Neocarzinostatin
Healthcare Provider Resources
Symptoms of Neocarzinostatin Causes & Risk Factors for Neocarzinostatin Diagnostic studies for Neocarzinostatin Treatment of Neocarzinostatin
Continuing Medical Education (CME)
CME Programs on Neocarzinostatin
International
Neocarzinostatin en Espanol Neocarzinostatin en Francais
Business
Neocarzinostatin in the Marketplace Patents on Neocarzinostatin
Experimental / Informatics
List of terms related to Neocarzinostatin

Please Take Over This Page and Apply to be Editor-In-Chief for this topic: There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us [1] to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch.

Neocarzinostatin is a macromolecular chromoprotein antibiotic with anti-tumoral activity secreted by Streptomyces macromomyceticus.

It consists of a labile chromophore (bicyclic dienediyne structure, Mr = 659) that is tightly and non-covalently bound to an apoprotein (113 amino acids) with high affinity (Kd ~ 10^-10M). The chromophore is a very potent DNA-damaging agent; it is very labile and the role of the apoprotein is to protect it and release it to the target DNA. Other members of the Neocarzinostatin group of antibiotics are macromomycin, actinoxanthin, kedarcidin and maduropeptin.