Thioacetazone

Thioacetazone

Clinical data
Routes of administration	Oral
ATC code	J04AM04 (WHO)
Identifiers
IUPAC name N-[4-[(carbamothioylhydrazinylidene) methyl]phenyl]acetamide
CAS Number	104-06-3
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C10H12N4OS
Molar mass	236.3

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Thioacetazone(INN and BAN) is also called thiocetazone, thiacetazone, thiosemicarbazone, benzothiozane or amithiozone(USAN); abbreviated T.

Thioacetazone is used in the treatment of tuberculosis; it has only weak activity against Mycobacterium tuberculosis and is only useful in preventing resistance to more powerful drugs like isoniazid and rifampicin. It is never used on its own to treat tuberculosis; it is used in a similar way to ethambutol. Thioacetazone is the only anti-TB drug that is ineffective when given intermittently.

There is no advantage to using thioacetazone if the regimen used already contains ethambutol, but many countries in sub-Saharan Africa still use thioacetazone because it is extremely cheap. Use of thioacetazone is declining because it can cause severe (sometimes fatal) skin reactions in HIV positive patients.

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