Cerulenin

Cerulenin is an antifungal antibiotic that inhibits sterol and fatty acid biosynthesis. In fatty acid synthesis, reported to bind in equimolar ratio to b-keto-acyl-ACP synthase. In sterol synthesis, inhibits HMG-CoA synthetase activity. It is also shown to inhibit feeding and induce dramatic weight loss in mice. It is found naturally in the Cephalosporium caerulensfungus.

References

• Huang P, Zhu S, Lu S, Dai Z, Jin Y.

An experimental study on cerulenin induced apoptosis of human colonic cancer cells. Zhonghua Bing Li Xue Za Zhi. 2000 Apr;29(2):115-8.

• Straub SG, Yajima H, Komatsu M, Aizawa T, Sharp GW.

The effects of cerulenin, an inhibitor of protein acylation, on the two phases of glucose-stimulated insulin secretion. Diabetes. 2002 Feb;51 Suppl 1:S91-5.