Diethylcarbamazine

Diethylcarbamazine

Clinical data
ATC code	P02CB02 (WHO)
Identifiers
IUPAC name 4-methyl-N,N-bis (4-methylpiperazin-2-yl)- piperazine-1-carboxamide
CAS Number	90-89-1
PubChem CID	3052
DrugBank	APRD00918
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C10H21N3O
Molar mass	199.293 g/mol

Diethylcarbamazine (DEC) is an anthelmintic drug that does not resemble other antiparasitic compounds. It is a synthetic organic compound which is highly specific for several parasites and does not contain any toxic metallic elements.

Uses

DEC is indicated for treatment of individual patients with certain filarial diseases. These diseases include: lymphatic filariasis caused by infection with Wuchereria bancrofti, Brugia malayi, or Brugia timori; tropical pulmonary eosinophilia, and loiasis.

In cases of onchocerciasis, another common filarial parasite, the drug is not used. This is because the itching associated with the dead subcutaneous parasites causes intense and unbearable itching.

DEC continues to be the mainstay for treatment of patients with lymphatic filariasis and loiasis. DEC is also used in the prevention of dog heartworm Dirofilaria immitis.

Mechanism

DEC is an inhibitor of arachidonic acid metabolism in filarial mf. This makes the mf more susceptible to immune attack.

Trade names

• Hetrazan
• Carbilazine
• Caricide
• Cypip
• Ethodryl
• Notézine
• Spatonin
• Filaribits
• Banocide Forte

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