Desogestrel

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Desogestrel

Clinical data
ATC code	G03AC09 (WHO)
Pharmacokinetic data
Protein binding	98.3%
Identifiers
IUPAC name 13-ethyl-17-ethynyl- 11-methylidene- 1,2,3,6,7,8,9,10,12,13,14,15, 16,17- tetradecahydrocyclopenta[a] phenanthren-17-ol
CAS Number	54024-22-5
PubChem CID	40973
DrugBank	APRD00762
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C22H30O
Molar mass	310.473 g/mol

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Desogestrel is a molecule used in hormonal contraceptives.

Controversy

In February of 2007, the consumer adovcacy group Public Citizen released a petition requesting that the FDA ban oral contraceptives containing desogestrel, citing studies going as far back as 1995 that suggest the risk of dangerous blood clots is doubled for women on such pills in comparison to other oral contraceptives.

Most combined oral contraceptive pills (COCPs, or simply OCs) on the market today contain both an estrogen compound (ethinyl estradiol is common) plus a progestin (a progesterone-like compound) such as desogestrel.

As such, desogestrel-containing birth control pills are sometimes referred to as "third generation" oral contraceptives. Drugs cited specifically in the petition include Apri-28, Cyclessa, Desogen, Kariva, Mircette, Ortho-Cept, Reclipsen, Velivet and some generic pills. Birth control pills that are considered "second generation" (Ortho Tri-Cyclen, for example) contain an estrogen and a progestin, but the progestin is different, such as levonorgestrel.

The dispute is whether third generation OCs are less safe than the second generations OCs, which are considered the current "gold standard" in terms of oral contraceptive safety.

See also

• Progestin

References

• Public Citizen’s Health Research Group: Petition to the U.S. Food and Drug Administration to Ban Third Generation Oral Contraceptives Containing Desogestrel due to Increased Risk of Venous Thrombosis HRG Publication #1799, 2007