Aminoglutethimide

Aminoglutethimide

Clinical data
Pregnancy category	D: (USA) D:(AUS)
Routes of administration	Oral
ATC code	L02BG01 (WHO)
Pharmacokinetic data
Bioavailability	>95%
Metabolism	Hepatic
Elimination half-life	12.5 ± 1.6 hours
Excretion	Renal
Identifiers
IUPAC name 3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione
CAS Number	125-84-8
PubChem CID	2145
DrugBank	APRD00592
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C13H16N2O2
Molar mass	232.278 g/mol

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Aminoglutethimide blocks the conversion of cholesterol to pregnenolone by inhibiting the enzyme desmolase, thus inhibits synthesis of all hormonally active steroids. It can be used in conjunction with other drugs for treatment of steroid-producing adrenocortical cancer.

Its major side effects are liver toxicity, inhibition of cortisol in the human body, and it may also cause hypothyroidism. Since cortisol helps break down muscle, aminoglutethimide is used by bodybuilders in a steroid cycle.

It is still used to suppress corticosteroid production in Cushing's Syndrome.

See also

• Glutethimide

External links

• Medline Plus