Hypertriglyceridemia omega-3 fatty acids
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Priyamvada Singh, M.B.B.S. [2]
Overview
Treatment of hypertriglyceridemia is by restriction of carbohydrates and fat in the diet, as well as with niacin, fibrates and statins (three classes of drugs). Increased fish oil intake may substantially lower an individual's triglycerides.[1][2][3].
Trial supportive data
Study on effect of combination of Omega-3 fatty acid and Simvastatin on hypertriglyceridemia [4]
- Source & year – Heart, 2001
- Study question – An omega-3 polyunsaturated fatty acid concentrate (Omacor) administered for one year decreased triglycerides in simvastatin treated patients with coronary heart disease and persisting hypertriglyceridaemia
- Study Population and intervention – 59 patients with CHD, receiving simvastatin 10-40 mg daily with serum triglycerides > 2.3 mmol/l, were either given Omacor (84% omega-3 fatty acid) 2 g BD or placebo for 24 weeks
- Study design – Double blinded randomized controlled trial
- Study period – 1 year
- Study results – Combination of Simvastatin with Omacor compared with placebo or baseline resulted in:
- Decrease in serum triglycerides by 20-30% (p<0.005)
- Decrease in very low-density lipoprotein (VLDL) cholesterol by 30-40% (p<0.005)
- Study conclusion - Omacor combination with simvastatin (concentrated source of omega-3 fatty acids) was found to be a safe and effective in decreasing serum triglycerides level in a study over one year in coronary heart disease patients and hypertriglyceridemia
External links
http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=184
References
- ↑ "Lipids Online Slides: hypertriglyceridemia, ICAM-1, fish oil, E-selectin".
- ↑ Terres W, Beil U, Reimann B, Tiede S, Bleifeld W (1991). "[Low-dose fish oil in primary hypertriglyceridemia. A randomized placebo-controlled study]". Zeitschrift für Kardiologie (in German). 80 (1): 20–4. PMID 2035283.
- ↑ "Fish oils in hypertriglyceridemia - Fish Oils Revisited Nutrition Research Newsletter - Find Articles".
- ↑ Durrington PN, Bhatnagar D, Mackness MI, Morgan J, Julier K, Khan MA; et al. (2001). "An omega-3 polyunsaturated fatty acid concentrate administered for one year decreased triglycerides in simvastatin treated patients with coronary heart disease and persisting hypertriglyceridaemia". Heart. 85 (5): 544–8. PMC 1729738. PMID 11303007.