Cardiology overview prevention

Cardiology Overview
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Antiplatelets and antithrombins
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Pulmonary hypertension
Stable angina
Valvular heart disease
Venous thromboembolism

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Statin Therapy

Drug Interactions

• Cyclosporin co-administration is associated with a higher rate of myositis among statin users as a result of inhibition of CYP3A4. The exception is pravastatin in which this is not a problem.

Myositis

• The risk of myositis is lowest with pravastatin and is not improved with switching to atorvastatin. Simvastatin at a dose of 80 mg is associated with a particularly high incidence of myositis.

Reducing non-myositis Muscle Pain

• Coenzyme Q can be used to reduce the incidence of non-myositis muscle pain. Several weeks of coenzyme Q should be administered prior to trying the combination of the agent with statin therapy.