Bivalirudin mechanism of action

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Mechanism of action

1) Specific and reversible direct thrombin inhibitor

2) Binds to the catalytic and anionic sites of both circulating and clot-bound thrombin.

3) Catalytic binding site occupation functionally inhibits coagulant effects by preventing thrombin-mediated cleavage of fibrinogen to fibrin monomers, and activation of factors V, VIII, and XIII.